Carboplatin Injection
Category: Anticancer
Each vial contains:-
Carboplatin….. 150mg ,450 mg and 600 mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with –SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.
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Composition : |
150mg,/15ml, 450mg/45ml |
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Indication : |
Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer. |
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Dosage :- |
Admin by slow infusion 10-60 mg or as required. |
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Contra Indications :- |
Pregnancy, lactation hypersensitivity, renal impairment. |
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Special Precautions :- |
Maintain good hydration. Shock like state sometimes occurs during i.v. infusion,. Monitor haematological, neurological status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia. |
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Paediatrics : |
Not usually prescribed. The risk of hearing loss is increased. |
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Pregnancy :- |
Not usually prescribed. |
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Lactation :- |
Not advised. |
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Elderly :- |
Reduced dose may be necessary. |
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Side Effects :- |
Nausea, vomiting, Tinnitus, deafness, neuropathy, nephrotoxicity, electrolyte imbalance. |
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Drug Interactions :- |
Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs. Synergistic with 5-fluorouracil and etoposide. |
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Purity : |
Not less than 99%. |
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