Category: Anticancer MANUFACTURER
Each vial contains:-
Doxorubicin….. 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.
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Composition : |
10mg/5ml, 50mg/25ml |
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Indication : |
Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas. |
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Dosage :- |
1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj. |
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Contra Indications :- |
Cardiac disease. Hepatic dysfunction. |
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Special Precautions :- |
ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure. |
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Paediatrics : |
Reduced dose necessary. |
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Pregnancy :- |
Not usually prescribed. |
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Lactation :- |
Not prescribed. |
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Elderly :- |
Reduced dose may be necessary. |
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Side Effects :- |
Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage. |
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Drug Interactions :- |
Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity. |
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Purity : |
Not less than 99%. |
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