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Product Name:
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Recombinant Homo sapiens (Human) Protein CYR61
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Product Type :
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Recombinant Protein
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Code :
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CSB-EP006463HU
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Size :
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1mg/500ug/200ug/50ug/10ug
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Uniprot NO. :
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Storage :
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Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
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Relevance :
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Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
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References :
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"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts." Chen C.-C., Mo F.-E., Lau L.F. J. Biol. Chem. 276:47329-47337(2001)
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Storage Buffer :
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20mM Tris-HCl based buffer,pH8.0
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Alias :
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CCN family member 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 Short name: IBP-10 Short name: IGF-binding protein 10 Short name: IGFBP-10 Protein GIG1
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Species :
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Homo sapiens (Human)
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Purity :
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Greater than 90% as determined by SDS-PAGE.
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Sequence :
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TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD
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Research Area :
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Stem Cells
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Link: w w w . cusabio . c o m
