Introduction

L-alpha-glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural compound found in the brain. It is also a precursor which may have potential for the treatment of and . Alpha-GPC is also used as a to enhance memory and cognition.

Alpha-GPC is found as a naturally occurring constituent of red meat products and organ tissue but for the most part is scarce in appreciable amounts in naturally occurring sources. Most supplements containing Alpha-GPC are made synthetically, where it can be enzymatically created from egg or . Due to this synthesis and the source, it is sometimes referred to as a semisynthetic derivative of lecithin.

Alpha-GPC rapidly delivers to the brain across the and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status.

 

Chemistry

Chemical Name: L-alpha-glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)

Molecular Formula: C₈H₂₀NO₆P

Molecular Weight: 257.22

CAS Number:28319-77-9

Appearance: White to off-white crystalline powder

Solubility: Walter-solution

Stability: Stable for at least 24 months

 

Manufacturing Process   

Alpha-GPC is produced inChinaby the one-step method, only use the green solvent ethanol and DI water.

 

Safety Studies

Rat(Oral):

Acute toxicity test                  LD50    10,000mg/kg

26-weeks repeatedtoxicity           NOAEL  > 100mg/day

Human(Oral):

300mg/day                        No toxicity

1200mg/day                       No toxicity

 

Recommended Daily Intake

300mg Alpha-GPC/day (Max 1200mg Alpha-GPC/day)

 

Storage

Store at low temperature in a well-closed container away from moisture and direct sunlight.