for the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. this introduced substance is Contrast Media, also known as IV contrast agents. As the first in China, Beilu Pharma launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a professional contrast media manufacturer, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.
Types of Contrast Media in Pharma
MRI CONTRAST MEDIA
Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the is more stable and less likely to release gadolinium ions.
Our dedication to your requirements, providing a full range of Contrast Media products
Finished product list
S. No |
Product name |
Characteristic |
Specification |
1 |
Gadopentetate Dimeglumine Injection |
Injectable solution |
469mg/ml: 10ml, 12ml, 15ml, 20ml |
2 |
Gadobutrol Injection |
Injectable solution |
604.72mg/ml: 7.5ml |
3 |
Ferric Ammonium Citrate Effervescent Granules |
Oral granules |
3G:0.6g(Fe 129mg) 6g:1.2g(Fe 258mg) |
4 |
Iopamidol Injection |
Injectable solution |
300mgI/ml: 50ml, 100ml 370mgI/ml: 50ml, 100ml |
5 |
Iodixanol Injection |
Injectable solution |
270mgI/ml: 100ml 320mgI/ml: 50ml, 100ml |
6 |
Iohexol Injection |
Injectable solution |
300mgI/ml: 20ml,50ml,75ml, 100ml 350mgI/ml: 20ml, 50ml, 100ml |
API & Intermediates Product list
S. No |
Products |
CAS NO. |
Packings |
Classification |
1 |
Iohexol |
66108-95-0 |
25kg |
Contrast agent |
2 |
Iodixanol |
92339-11-2 |
25kg |
Contrast agent |
3 |
Iopromide |
73334-07-3 |
25kg |
Contrast agent |
4 |
Iopamidol |
60166-93-0 |
25kg |
Contrast agent |
5 |
Ioversol |
87771-40-2 |
25kg |
Contrast agent |
6 |
Gadopentetate Monomeglumine |
92923-57-4 |
25kg |
Contrast agent |
7 |
Gadopentetate Dimeglumine |
86050-77-3 |
25kg |
Contrast agent |
8 |
Gadobutrol |
138071-82-6 |
25kg |
Contrast agent |
9 |
Calcobutrol |
151878-23-8 |
2kg |
Excipients |
10 |
Repaglinide |
135062-02-1 |
10kg |
Anti-diabetic |
11 |
Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA) |
67-43-6 |
2.5kg |
Intermediates |
12 |
IOPAMIDOL INTERMEDIATE (order based) 5-Amino-2,4,6-triiodoisophthalic acid |
35453-19-1 |
25kg |
Intermediates |
Comparison of physicochemical characteristics of commonly used Contrast Media
Contrast media (Concentration:mg(I)/ml) |
Osmotic pressure (mOsm/kg water) |
Viscosity (cP,37℃) |
Iopamidol 300 |
616 |
4.7 |
Ioverol 300 |
651 |
5.5 |
Iohexol 300 |
672 |
6.3 |
Iobitridol 300 |
695 |
6 |
Iodixanol 320 |
290 |
11.8 |
the osmotic pressure of normal people is about 290-300mOsm/kg.
Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.
Three factors of renal injury induced by intravascular contrast media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.
Beijing Beilu Pharmaceuticals Company Limited is a professional anti-anxiety drugs manufacturer, we provideImaging agents,Ct cisternography contrast and etc. Want to knowIV contrast medication contraindications or more? Contact us now.
