Irinotecan hydrochloride is a derivatives of camptothecin as pale yellow powder, soluble in water, methanol, sparingly soluble in chloroform, and practically insoluble in acetone. It is a Top I inhibitor, primarily used in the treatment for colorectal cancer as first-line drug. And it also can exhibit efficacy for non-small-cell lung cancer, stomach cancer, pancreas cancer, Ovarian cancer.