PVP-P behaves as a white or creamy white powder with faint characteristic odor, which is easily hydrophilic and capable of complex with such substance as phenol, etc. It is completely insoluble with relatively high crosslink density and does not form gels that can impede disintegration, dissolution and drug release.
Product name :Crospovidone
CAS No. : 9003-39-8
Molecular formular: ( C6H9NO)n
Molecular weight: more than 1 000 000
Chemcial name:1-Ethenyl-2pyrrolidinone homopolymer
Key words: Polyvinylpolypyrrolidone, PVP-P,Crospolyvidone, insoluble polyvinylpyrrolidone crospovidone,crospolyvidonum, ,crosslinked PVP,
Chemical Structure: Polyvinylpyrrolidone crosslinked
Specification: Pharmaceutical grade
|
Product |
Pharm grade |
|
Appearance |
White or yellowish-white powder or flakes |
|
Water-soluble substances % max. |
1.0 |
|
pH Value (1% in water) |
5.0-8.0 |
|
Loss on Drying % max |
5.0 |
|
Sulphate ash % max |
0.1 |
|
Nitrogen Cotent % |
11.0-12.8 |
|
Impurity A(Vinylpyrrolidone) ppm max |
10 |
|
Peroxide(As H2O2) ppm max |
400 |
|
Heavy metals ppm max |
10 |
|
Partical size (μm), ≥80% |
50-250 |
Application:
To assure the effectiveness of the medicine,tablets and capsules are required to disintegrate within a certain time,if different adding methods of the disintegrating agent are used,the different disintegrating and dissolution speeds witll be achieved.PVPP is regarded as the top disintegrating agent thanks to its excellent swelling characteristics after the absoption of moisture.
a. Highly efficient disintegrating agent: Makes all excipients swell quickly,effective for wet & dry granulations and direct compression formulations,PVPP can be added before or after granulation.Its swelling action and disintegration time will be not impacted by wetting or drying.
b. Suspension stabilizer:PVPP acts as a hydrophilic polymer,increasing the viscosity,improving the dispersal capacity,reducing the sedimentation rate of drugs,meanwhile,increasing the redispersal capacity of the solution sediment,suitable for liquid preparations and instant oral preparations.
c. Complextant of drug ingredients:Stablizing the active ingredients in pharmaceutical products,improving the dissolution and bioavailability.
d. Moisture Absorbent.
Storage: should be preserved in tight container.
Packaging: 20 kg / drum
Period of validity:3 years