Sennosides are the purgative principles of these plants ~ and like other glycosides are metabolized by animals and humans into monomeric rhein or other anthraquinones which are the active metabolites. The natural free anthraquinones are not effective and it has been confirmed that they are reduced into anthrones and anthranoles in the human intestine, and act as laxative compounds The stimulant laxatives composed of the anthraquinones are the cause of the greatest side-effects and are often abused by the public, therefore the identification and analysis of anthraquinones in herbal samples, pharmaceutical preparations and biological fluids are of greatimportance. |