Name: Lamivudine

Synonyms: 2′, 3′-Dideoxy-3′-thiacytidine, 3TC, Epivir-HBV, Epivir, Heptovir, Zeffix
Molecular formula: C8H11N3O3S
Molecular weight: 229.26
CAS NO: 134678-17-4

Appearance: white crystalline powder

Function and Usage: Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

 

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