Physical Character:

 

*The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.

 

Clinical Pharmacology

 

* Nicotinamide is a water-soluble component of the vitamin B complex group.

 

* In vivo, Nicotinamide is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD and NADP function as coenzymes in a wide variety of enzymatic oxidation-reduction reactions essential for tissue respiration, lipid metabolism, and glycogenolysis.

 

* Nicotinamide has demonstrated anti-inflammatory actions which may be of benefit in patients with inflammatory acne vulgaris, including but not limited to suppression of antigen induced-lymphocytic transformation and inhibition of 3'-5' cyclic AMP phosphodiesterase.

 

* Nicotinamide has demonstrated the ability to block the inflammatory actions of iodides known to precipitate or exacerbate inflammatory acne.

 

* Nicotinamide lacks the vasodilator, gastrointestinal and hepatic actions of nicotinic acid or niacin. As such nicotinamide has not been shown to produce the flushing, itching and burning feeling of the skin, as is commonly seen when large doses of nicotinic acid or niacin are administered orally.