Name:Alon-emodin
CAS No.:481-72-1
Molecular formula:C15H10O5
Molecular weight:270.24
Specification:98%
Appearance:orange powder
Fuction and usage:
aloe-emodin(AE), a hydroxaynthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antieeuroectodermal tumor activity. The groeth of human neuroectodermla tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound dose not inhibit the proliferation of nomal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, where the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action. AE might represent a conceptually new lead antitumor drug.
CAS No.:481-72-1
Molecular formula:C15H10O5
Molecular weight:270.24
Specification:98%
Appearance:orange powder
Fuction and usage:
aloe-emodin(AE), a hydroxaynthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antieeuroectodermal tumor activity. The groeth of human neuroectodermla tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound dose not inhibit the proliferation of nomal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, where the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action. AE might represent a conceptually new lead antitumor drug.