Active Ingredient: Flax Lignans Lignans SDG Secoisolariciresinol Diglycoside
Specification: 25%
Test Method: HPLC
Secoisolariciresinol Diglycoside (SDG) Flax Lignans Flaxseed Oil EXtract Flaxseed hull EXtract Lignans SDG Linum usitatissimum Secoisolariciresinol Diglycoside
Secoisolariciresinol diglycoside, or SDG, is a plant lignan most notably found in flaxseed (linseed). SDG is classified as a phytoestrogen since it is a plant-derived, nonsteroid compound that possesses estrogen-like activity. SDG has weak estrogenic activity. The level of SDG in flaxseed typically varies between 0.6% and 1.8%.
Lignans are one of the two major classes of phytoestrogens; the other class is the isoflavones. Plant lignans are polyphenolic substances derived from phenylalanine via dimerization of substituted cinnamic alcohols. Mammalian lignans are lignans derived from plant lignans. For example, following ingestion, SDG is converted to the aglycone secoisolariciresinol, which is then metabolized to the mammalian lignans enterolactone and enterodiol. Most of the effects of oral SDG are mediated by enterolactone and enterodiol.
The molecular formula of SDG is C32H46O16, and its molecular weight is 686.71 daltons. The aglycone of SDG is also known as 2, 3-bis (3-methoxy-4-hydroxybenzyl) butane-1, 4-diol. Enterolactone is also known as trans-2, 3-bis [(3-hydroxylphenyl) methyl]-butyrolactone. It is represented by the following structural formula:
SDG has estrogenic and antioxidant activities. It may also have antiestrogenic, anticarcinogenic, antiatherogenic and antidiabetic activities.
SDG has estrogenic and antioxidant activities. It may also have antiestrogenic, anticarcinogenic, antiatherogenic and antidiabetic activities. Research suggests lignans may benefit consumers in the following areas:
Metabolism and mechanism of lignans
Lignans are natural compounds with two or three molecules of benzene propyl′s combination by various modalities. Being phytoestrogen, flax lignans can bind to estrogen receptors and interfere hormone metabolism as soya isoflavones and red clover isoflavones. The main ingredient of flax lignans is secoisolariciresinol diglucoside (so called SDG), SDG is the precursor of mammal lignans because it is converted into enterolactone (EL) and enterodiol (ED) after ingestion because of hydrolyzed and participation of enzyme as well as colonic bacteria. Dietary flaxseed obviously increases EL and ED