Apple tree bark is tonic and febrifuge, and a decoction of it has been used with advantage in intermittent, remittent, and bilious fevers, and in convalescence from exhausting diseasesPhloridzin is tonic and antiperiodic, and has cured cases of intermittent fever, even where quinine has proved ineffectual; its dose is from 5 to 20 grains. Unlike quinine, it does not cause gastralgia.