Molecular formula: C₆₅H₇₃Cl₂N₉O₂₄·HCl (M.W. 1471.71)
Application
Tricyclic glycopeptide antibiotic indicated for initial therapy in the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci, such as endocarditis, septicemia, bone and joint infections, lower respiratory tract infections, and skin and skin structure infections. For endocarditis caused by Enterococci (eg, Enterococcus faecalis), it is effective only in combination with an aminoglycoside. It is successfully used in combination with either rifampin or an aminoglycoside, or both in early-onset prosthetic valve endocarditis caused by Staphylococcus epidermidis or diphtheroids. The parenteral form may be administered orally for treatment of antibiotic-associated pseudomembranous colitis caused by Clostridium difficile and for Staphylococcal enterocolitis. It is also indicated for penicillin-allergic patients.
Specification
ChP