Name: Tacrolimus
Synonyms: (2-propenyl)-,(3s-(3r*(e
(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))
-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-
methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)
oxazacyclotricosine-1,7,20,21(4h,23h)-
tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-
5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-
dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-
dihydroxy-5;fr900506;prograf;tsukubaenolide
CAS NO: 104987-11-3
Formula: C44H69NO12
Formula Weight: 804.02
Properties: White Crystalline Solid
mp : 113-115°C
storage temp. : ?20°C
solubility : DMSO: >3 mg/mL
Purity:99% HPLC
Package: 20g/Aluminum foil bag
Usage: An immunosuppressant that blocks T cell proliferation in vitro
by inhibiting the generation of several lymphokines, especially IL-2.
Shown to inhibit the activity of FK-506 binding protein, thereby
reversing its effects on sarcoplasmic reticulum Ca+2 release.