This machine can constitute the double-color, 3-color and 4-color printing & slotting machines and can accomplish the processes such as printing, separate cutting, creasing, slotting and corner cutting in one time. Base upon absorbing the advantages of the same kind of products, this machine adopts the complete new design which has the features such as beautiful outward appearance, novel, compact structure, high clarity of printing, small error of color process, convenient and accurate regulating and so on. It can also accomplish the gear driving without space and the phase of the printing roller can be adjusted in 360without stopping the machine. This machine has two forms of structure, i. e. hand and pneumatic. The pneumatic structure can carry out pneumatic ink supplying, automatic inking and separating of the inking roller and the printing plate, which has raised the operation and operating speed. The automatic ink distributing mechanism can prevent the ink from being dried out and coagulative while stopping the machine and adjusting, which has prolonged the service life of the anilox and rubber rollers.