Plant origin: extract from whole herb and leaf of Acanthaceae plant Andrographis (Andrographis paniculata (Burm.f.) Nees)

Chemical ingredient: andrographolide, neoandrographolide, 14-deoxy andrographolide, andrographoside, 14-deoxyaandrographoside, Dehydroandrographolide lactones and flavonoids.

Specifications: Andrographis extract ( total lactone content from 5 to 30% ); andrographolide content more than 99%; dehydroandrographolide; Neoandrographolide.

Andrographis extract

Name: Andrographis dry extract, Andrographolide

Characters: Andrographis extract is dark green or brown ( after bleaching ) powder or lumps, odorless, very bitter taste.

Content: Dry extract contains paniculta lactone, dehydration paniculta lactone is 5 ~ 30%

Method: HPLC method (refer to Chinese Pharmacopoeia 2010 edition)

Standard: Corporate standard

Andrographolide

Molecular formula:C20H30O5

Molecular Weight: 350.44

CAS number:5508-58-7

Properties: white square prismatic or crystals flakes ( ethanol or methanol ), odorless, bitter taste. Dissolved in boiling ethanol,slightly soluble in methanol or ethanol, very slightly soluble in chloroform, almost insoluble in water and ethyl ether<STRONG
</STRONG

Melting point 230 ~ 231 centigrade degree

Content: above 99%

Method: HPLC method

Dehydroandrographolide

Molecular formula: C20H28O4

Molecular Weight: 332.42

Properties: Colorless crystalline needle (30% or 50 % ethanol ), freely soluble in ethanol, acetone, soluble in chloroform, slightly soluble in benzene, almost insoluble in water. Melting point 204 centigrade degree.

Content: above 99%

Method: HPLC method

Neoandrographolide

Chemical name: 19-hydroxy-8 (17) ,13-laboiadien-16,15-olide-o-βD-glucopyranoside

CAS number: 27215-14-1

Molecular formula: C26H40O8

Molecular Weight: 480.58

Properties: colorless columnar crystals, no bitterness. Soluble in methanol, ethanol, acetone and pyridine, slightly soluble in chloroform and water, insoluble in ethyl ether and petroleum ether.

Melting point 167 ~ 168 centigrade degree, boiling point 668.1 centigrade degree, the refractive index of 1.576 , flash point 220.1 centigrade degree, density: 1.27g/cm3, optical rotation [α] D-48 degree ( pyridine ), -45 degree (c = 1, ethanol ).

Content:above 98%

Method: HPLC method

Pharmacology efficacy: Neoandrographolide has function of heat-clearing and detoxifying, relieve swelling and pain. Animal experiments show that it inhibit and delay fever effect caused by the pneumococcus and hemolytic streptococcus. Also has inhibition cough and asthma. Suitable for the treatment of acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, faucitis, and so on.