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Resveratrol

Resveratrol is a polyphenolic compounds , mainly from grapes ( red wine ) , knotweed , peanuts, mulberry and other plants . Resveratrol is a natural biological strong polyphenols , also known as Qi three phenol, is cancer chemopreventive agent , but also to reduce platelet aggregation, prevention and treatment of atherosclerosis , cardiovascular and cerebrovascular diseases chemopreventive agent. USDA 's findings show that the peanut kernel also contains red and quite a lot of resveratrol. Experimental studies have shown that resveratrol has on cardiovascular disease and cancer beneficial effect. Resveratrol on hormone-dependent tumors have significant preventive effect. Also on osteoporosis, acne and dementia have a preventive effect , with anti- virus and immune regulation. One monomer on the body's internal anti-aging enzymes play a role, and then play the prevention of various age-related diseases, the potential role of life expectancy .

Basic information


Instructions for use

As a selective inhibitor of COX-1 ; a discovery in grape skins and other plants phenolic phytoalexin , for the protection of plant cells and to prevent fungal attack . For animals , resveratrol has antioxidant activity and intracellular activation of SIRT1 gene expression ; one kinds of NAD + -dependent histone deacetylase , contained in mitochondrial biogenesis and in enhanced activation of peroxisome γ proliferator receptor coactivator -1α (PGC-1α) and FOXO activity ; resveratrol 's anti-diabetic , neuroprotective and inhibit fat behavior may be contributed through SIRT1 activation .

Pharmacological effects

Resveratrol is a natural antioxidant , can reduce blood viscosity , inhibiting platelet aggregation and vasodilation to maintain blood flow , can prevent the occurrence and development of cancer , has anti- atherosclerosis and coronary heart disease , ischemic heart disease, high blood cholesterol in rats . Role in tumor suppression also has estrogen-like effects that can be used to treat breast cancer and other diseases.

Antipyretic and analgesic effect

Resveratrol through a variety of different ways to play a therapeutic effect, with certain antipyretic and analgesic activity. Mice and rats in the full body of research shows that resveratrol does not affect blood pressure in the case confer resistance due to gastric secretion of gastric mucosa caused by the suppression of stress ulcer capabilities.

Anti-cancer , anti- mutagenic effect

1993 , Jayafilake other studies show that trans -resveratrol and cis -resveratrol has anti-cancer activity , the reason is that they can inhibit protein - tyrosine kinase activity . Jang et research team further noted that resveratrol in cancer occurs three phases namely initiation, promotion and development process, has a greater anti-cancer activity, and on the three stages of cancer inhibition and even reversal effect : First , the initial inhibition effect. Reduce the formation of free radicals , pharmacokinetic enzyme induction phase Ⅱ increased dioxin antagonistic role ; Second, to enhance the role of inhibition . Inhibition of cyclooxygenase (COX), inhibition of catalase ; three inhibiting development role . Inhibit cancer cell proliferation and induce cell differentiation , induction of apoptosis in cancer cells . Resveratrol is expected to PTK as protein tyrosine kinase inhibitors , many medical study found that resveratrol on breast cancer, stomach cancer, colon cancer, prostate cancer, leukemia , ovarian cancer, skin cancer and other malignant cell significantly inhibited .

Cardiovascular protection

In the private sector, has long been used in traditional Chinese medicine Polygonumcuspidatum resveratrol -rich treatment and prevention of high cholesterol, arteriosclerosis. Studies have shown that resveratrol mainly from the following aspects play an anti- atherosclerosis , coronary heart disease prevention and thus play a protective effect on the cardiovascular : 1, regulating blood lipids ; 2 , inhibition of platelet aggregation , and promote fibrinolysis, anti-thrombotic forming effect; 3, the protection of vascular endothelium, inhibition of endothelial cell proliferation ; 4, protection of vascular smooth muscle cells, inhibit the proliferation ; 5 , anti-leukocyte function ; 6 , antagonizing endothelin -1 (endothelin-1, ET-1) effect; 7 , anti- LDL -oxidation function . Some studies , including toxins or thrombin -induced platelet activation in rats found washed platelets with resveratrol pre- incubation, at physiological concentrations in plasma LPS alone or LPS and thrombin activated platelets on collagen adhesion is blocked . Platelet adhesion pretreated with resveratrol fibrinogen have also been blocked . Resveratrol and its derivatives are more recent study of a class of phytoalexin , its cardiovascular protective effects gradually become a hot topic , is expected in the prevention and treatment of cardiovascular diseases, drug development make a difference, but its mechanism of action is far from clear , pending further study.

Prevention of heart and liver damage
Resveratrol inhibits mouse liver triglycerides and cholesterol deposition . It also can inhibit the liver lipid peroxidation which prompted aspartate aminotransferase and alanine aminotransferase levels rise. By analyzing these two enzymes in serum , liver, heart, and can be obtained in good diagnostic information.

Antithrombotic function
Resveratrol inhibits lipoxygenase synthesis , the enzyme present in leukocytes, heart, brain , lung and spleen . Therefore, resveratrol prevents the formation of blood clots in blood vessels . And the use of antihypertensive drugs such as clonidine treatment, it also inhibits platelet build-up.

Enhance the activity of the immune system
Resveratrol can also boost the immune system and promote healing of burns . Some studies of resveratrol in restoring scalded mice suppressed cellular , humoral and non-specific immune function , the effect of resveratrol used to provide a controlled drug dependence style immunomodulatory effects . Severe burns of different degrees study in mice showed that resveratrol restore their damaged functions, such as the ability to respond to antigen signals , proliferative capacity , interleukin Ⅱ synthesis capacity and capability through lymphocyte antibody synthesis . Severe burns of animals with controlled resveratrol treatment, the levels of neutrophils and the adhesion rate returned to near normal levels, but prolonged the survival time .

Anti-oxidation, anti-free radical action
Resveratrol is found in plants natural antioxidants , mainly by removing or inhibiting free radicals , inhibition of lipid peroxidation, antioxidant related enzymes regulating mechanisms such as an anti -oxidation . Most polyhydroxy stilbenes substances have antioxidant, anti-free radical effect. When resveratrol in 1.3μg / mL , can inhibit erythrocyte hemolysis and self- oxidation caused by the oxidation of H2O2 hemolysis of mouse heart, liver , brain and kidney in vivo lipid peroxidation produce inhibited. In addition to the antioxidant resveratrol induced free radicals and arachidonic acid metabolism affect the pharmacological function aroused widespread interest because these physiological metabolism is closely related to human health associated with many physiological diseases such as atherosclerosis , Alzheimer's disease , viral hepatitis , ulcers, inflammation and allergic reactions.

Anti-inflammatory, antibacterial
Resveratrol against Staphylococcus aureus, catarrhal bacteria, Escherichia coli , Pseudomonas aeruginosa are inhibited , and the orphan virus, herpes simplex virus and enterovirus , Coxsackie A, B group was strongly inhibited . Resveratrol by reducing platelet adhesion , platelet anti-inflammatory activity of the process to achieve anti-inflammatory change .

Longevity
Pisa, Italy, a group of scientists through research found that grapes contain resveratrol can help fish life extension . Received more than 100 fish in the experiment , 30 were fed a small amount of resveratrol daily , 60 are fed amount, 20 are fed to great weight , the result of a group of fish was not seen what effect , the first two groups of fish life expectancy by 27 % in the first three groups of fish life expectancy by 50%. This is the first time scientists have found that resveratrol on vertebrate longevity effect.

The role of lipid-lowering diet
Because resveratrol has anti-cancer , anti-oxidation , anti-inflammatory , antibacterial action of love to the people's favorite, plant sources said that because the French often drink containing high fat substance resveratrol , so the French crown heart disease incidence rate at the end of the other Western countries , resveratrol can be learned from this information as effectively suppress high-fat rats. At present, some countries and regions to their products as a dietary supplement Resveratrol Resveratrol development .