In pharmaceuticals and dermatology, allantoin is used in the treatment of ulcers, slow-healing wounds and burns. Addition of it to wound ointments and healing compositions promotes wound cleansing and healing. Allantoin has been classified by the US FDA OTC Topical Analgesic Review Panel as a Category I active ingredient (skin protectant), at use-levels of 0.5~2.0%. The FDA approved applications include minor cuts, scrapes, burns, sunburn, fever blisters, diaper rash and chafed, chapped, cracked or wind burned skin and lips.
In cosmetics, allantoin is used in numerous preparations, where it enhances cell renewal, skin soothing, skin moisturizing, cleansing and healing action. In addition, it has the advantages of being non-toxic, non-irritating and effective in low concentrations. Allantoin promotes cell regeneration in skin exposed to and weakened by environmental factors, and helps to promote and maintain the health of intact skin on the body and face. Addition of it to hand lotions and hand creams helps eliminate rough, chapped skin, and leaves hands smooth and soft. In hair care, because of its extraordinarily good keratolytic properties, allantoin is a valuable additive in various products such as shampoos and hair gels, especially for the treatment of dandruff. Allantoin has been incorporated into various lotions and creams, lipsticks, aftershave balms, suntan products, bath foams, baby products and various aerosol preparations. It has also been used in oral hygiene products such as toothpaste and mouthwash. Its good compatibility with most relevant materials also allows it to be easily incorporated into existing formulations.
The recommended use level in cosmetics is 0.1~0.