R404A is widely used in low-temperature, often used in marine refrigeration equipment, industrial cryogenic refrigeration, commercial low temperature refrigeration, supermarket display cases and other refrigeration equipment. R404a is Newly refrigeration equipment,  the most common industry standard instead of R22 and R502 refrigerant. (usually a low temperature refrigeration systems), R404 is closest to the operation of R502 can be normal operation of the environment.