| Type: | Huperzine -A |
|---|---|
| Form: | Powder |
| Part: | Bark |
| Extraction Type: | Solvent Extraction |
| Packaging: | Glass Container,Mason Jar |
| Place of Origin: | China (Mainland) |
| Grade: | 98% |
| Brand Name: | 98% |
| Model Number: | 98% |
Quick Details
Specifications
This product by Shi Sha Huperzinaserrata plants multi-layer tower (Thumb) Trev a alkaloids extracted, is a potent cholinesterase reversible inhibitor, its function characteristics and neostigmine are similar, but their role to maintain time for longer than the latter.For true cholinesterase inhibition of selective, inhibit strength is mimicked cholinesterase thousands of times;Inhibition way as competitive and non-competitive hybrid suppressed, and simple competitive inhibitors were significantly different;Easy through the blood brain barrier
This product by Shi Sha plants multi-layer tower [Huperzinaserrata (Thumb) Trev ] an alkaloid extracted, is a potent cholinesterase reversible inhibitor, its function characteristics and neostigmine are similar, but their role to maintain time for longer than the latter.Animal experiments showed that the product of true cholinesterase inhibition of selective, is mimicked cholinesterase inhibition strength of thousands of times;Inhibition way as competitive and non-competitive hybrid suppressed, and simple competitive inhibitors were significantly different;Easy through the blood brain barrier into the center, and has the central and peripheral therapy effect;Effective time is long;Absorbed from the gastrointestinal tract is good;Safety index;Stability is good.Strength of inhibition of AChE compared the titer between the different drugs, the results as follows: huperzine a > physostigmine > neostigmine > Shi Sha alkali b > galantamine;Strength in the order: the restraint of the BuChE physostigmine > neostigmine > huperzine a > Shi Sha alkali b.[ strengthen indirect muscle contraction amplitude caused by electrical stimulation neural function, and enhance the effect of strengthen the memory function of rats were stronger than physostigmine, but lower than toxic physostigmine, effect time long.Acute toxicity test: the abdominal injection of LD50 is 1.8 mg/kg, the rat is 5 mg/kg.Clinical doses of subacute toxicity test, give the equivalent of 45 times, six months, the results have no obvious adverse reaction.In addition, also did not see teratogenic, mutagenic effect.
Huperzine a has been - "medicine generation of dynamics"
Because of the very few dosage of this product, there is no drug detection method for human pharmacokinetic studies.In rats after abdominal injection or oral dosing of blood drug concentration time curve, conforms to two outdoor open model is analyzed by intravenous injection or oral dosing t1/2 alpha 6.7 min and 9.8 min.T1/2 beta 121.6 min and 247.5 min.Mice for 15 min after intravenous administration of kidney, liver content is the highest, followed by the lung, spleen, adrenal gland, fat, heart and brain.After 24 h, the viscera is close to the content of trace, a small amount of drugs can be through the placenta into the fetus.This article mainly through the kidneys after the treatment, 24 h discharge medication doses of 73.6%, from its droppings to drug doses (2.8 + 1.2) %.7 d in the amount of total emissions of injection in 86
[ indications ] this applies to goods benign memory disorders, cerebrovascular disease, brain trauma, organic mental disorders, peripheral vascular obstructive diseases, diabetic neuropathy, acute or chronic Achilles tendon pain, exercise-induced muscle damage.
This product by Shi Sha plants multi-layer tower [Huperzinaserrata (Thumb) Trev ] an alkaloid extracted, is a potent cholinesterase reversible inhibitor, its function characteristics and neostigmine are similar, but their role to maintain time for longer than the latter.Animal experiments showed that the product of true cholinesterase inhibition of selective, is mimicked cholinesterase inhibition strength of thousands of times;Inhibition way as competitive and non-competitive hybrid suppressed, and simple competitive inhibitors were significantly different;Easy through the blood brain barrier into the center, and has the central and peripheral therapy effect;Effective time is long;Absorbed from the gastrointestinal tract is good;Safety index;Stability is good.Strength of inhibition of AChE compared the titer between the different drugs, the results as follows: huperzine a > physostigmine > neostigmine > Shi Sha alkali b > galantamine;Strength in the order: the restraint of the BuChE physostigmine > neostigmine > huperzine a > Shi Sha alkali b.[ strengthen indirect muscle contraction amplitude caused by electrical stimulation neural function, and enhance the effect of strengthen the memory function of rats were stronger than physostigmine, but lower than toxic physostigmine, effect time long.Acute toxicity test: the abdominal injection of LD50 is 1.8 mg/kg, the rat is 5 mg/kg.Clinical doses of subacute toxicity test, give the equivalent of 45 times, six months, the results have no obvious adverse reaction.In addition, also did not see teratogenic, mutagenic effect.
Huperzine a has been - "medicine generation of dynamics"
Because of the very few dosage of this product, there is no drug detection method for human pharmacokinetic studies.In rats after abdominal injection or oral dosing of blood drug concentration time curve, conforms to two outdoor open model is analyzed by intravenous injection or oral dosing t1/2 alpha 6.7 min and 9.8 min.T1/2 beta 121.6 min and 247.5 min.Mice for 15 min after intravenous administration of kidney, liver content is the highest, followed by the lung, spleen, adrenal gland, fat, heart and brain.After 24 h, the viscera is close to the content of trace, a small amount of drugs can be through the placenta into the fetus.This article mainly through the kidneys after the treatment, 24 h discharge medication doses of 73.6%, from its droppings to drug doses (2.8 + 1.2) %.7 d in the amount of total emissions of injection in 86
[ indications ] this applies to goods benign memory disorders, cerebrovascular disease, brain trauma, organic mental disorders, peripheral vascular obstructive diseases, diabetic neuropathy, acute or chronic Achilles tendon pain, exercise-induced muscle damage.