SynPhase Lanterns - a modular solid phase platform as an alternative to resins

Characteristics of Ideal Solid Phase
1.Equivalent Reactivity of Functional Groups
   approach solution phase conditions
2.Physicochemical Compatibility
   with compounds being synthesized
   with polar and non-polar solvents
3.Good Mechanical Properties
    under wide range of solvent, temperature and pressures

Why Solid Phase Synthesis?
1.Simplifies parallel handling
2.Readily automated
3.Drive reactions to completion with excess reagent
4.Remove excess: reagents and
5.by-products by washing

Morphology of Solid Supports
Microporous gels
low cross-linked copolymers such as polystyrene (PS) , polyamides (PA), etc.

Macroporous or macroreticular resins
controlled-pore  glass or highly cross-linked polystyrene.

Pellicular  supports
composed of two layers
mobile accessible surface on a solid core material
eg. glass, PTFE (Polytetrafluoroethene),PP(polypropylene) or highly cross-linked PS
 
Lanterns:

Launched March 2000

Adopted as library synthesis platform by several big pharmaceutical companies

Polystyrene or Polyamide surface on polypropylene

Quantised solid phase

Can be used as Matrix Format or Direct sort format

Structure of Lantern Surface
Uniform 50 micron graft
High loading
Excellent kinetics
Temperature stability
(-80°C to 100°C )
Minimal swelling
Stable to agitation

SynPhaseTM technology used in Parallel mode

Lanterns (in white) fixed to stems (in blue) which are fixed to stem holder in 8x12 array format (96). This can now go into 96 well plate each having different reaction mixtures.

The Classic MultiPinTM Method
Simple handling
Convenient 8x12 array  format
Detachable stems
Ideal for washes and simultaneous cleavage

Any chemistry carried out on Resins is transferable to Lanterns with minimum modification

Synthesis of peptide VQAAIDYING on Rink Lanterns using a CEM DISCOVER MICROWAVE UNIT
Solution A  1.46 g HBTU in 10 mL DMF
Solution B  0.8 g HOBT in 10 mL DMF

Coupling solution
AA Production solution 0.82 mL  
Solution A 0.64 mL
Solution B 0.64 mL    
NMM 0.064 mL

Fundamental differences between SynPhase™ Lanterns and Resins

Handling convenience
Rapid and uniform kinetics
Rapid washing
Broad applications
solid phase synthesis
parallel synthesis, tagged based techniques
solution phase synthesis
scavengers, catch and release, support bound reagents
Cost effective