| Model Number: | W019 |
|---|---|
| Brand Name: | Wild White Biotechonlogy |
| Grade: | Cosmetic Grade,Food Grade,Medicine Grade |
| Place of Origin: | China (Mainland) |
| Packaging: | Bottle,Can,Drum,Glass Container,Vacuum Packed,1kg/bag25kg/drum,inner with vacuum packing or as the customer's requi, |
| Extraction Type: | Anesthetic AgentsAnti-Allergic Agents |
| Form: | Powder |
| Appearance: | white |
Quick Details
Specifications
1.English name:Topotecan
2.Molecular Formula:C23H23N3O5
3.Molecular Weight:421.4458
4.CAS Registry Number:123948-87-8
5.Quality:98%
6.Density:1.49g/cm3
7.Boiling point:782.9°C at 760 mmHg
8.Refractive index:1.733 Flash point:427.3°C
9.Vapour Pressur:8.13E-26mmHg at 25°C
|
Analysis Test |
Specification |
Result |
|
Description |
white crystalline powder,odorless |
Conforms |
|
Solubility |
Easily soluble in water, unsoluble in ethanol |
Conforms |
|
PH |
6.0~7.5 |
6.9 |
|
Solution clarity and color |
solution should be clear and colorless |
Conforms |
|
Related substances |
5'CMP 0.3% Simple impurity Total other impurity |
0.01% 0.03% 0.10% |
|
Chloride |
0.05% |
Conforms |
|
Ammonium |
0.05% |
Conforms |
|
Fe |
0.01% |
Conforms |
|
Phosphate |
0.1% |
Conforms |
|
Loss on drying |
≤6.0% |
1.3% |
|
Heavy metals |
0.002% |
Conforms |
|
Arsenide |
0.0001% |
Conforms |
|
Bacterial Endotoxins |
0.3EU/mg |
Conforms |
|
Microbial Limit |
Conforms |
Conforms |
|
Assay(on dried basis) |
≥98.0% |
98.8% |
|
Conclusion: The results conform with CP2010 |
||
1 Topotecan
Hydrochloride (Topotecan HCl) is a semi-synthetic derivative of camptothecin.
Camptothecin is a natural product extracted from the bark of the tree
Camptotheca acuminata. Topoisomerase-I is a nuclear enzyme that relieves
torsional strain in DNA by opening single strand breaks. Once topoisomerase-I
creates a single strand break, the DNA can rotate in front of the advancing
replication fork. Topotecan intercalates between DNA bases. This intercalation
disrupts the DNA deplication machinery when it reaches a site where topotecan
is intercalated.
2 Topotecan is an antineoplastic agent used to treat small cell lung
cancer, and certain cancers of the ovary.
3 Topotecan is also used to treat relapse of small cell lung cancer that
initially responded to other drugs. Increases in survival times have been
observed in patients treated with topotecan compared to control populations
treated with paclitaxel.