[ composition ]
Main ingredients: tamoxifen citrate. Its chemical name is: (Z) - N, N - dimethyl - 2 - [4 - (1, 2 - diphenyl - 1 - butylene) phenoxy] - ethylamine citrate salt.
[ properties ]
This product is a white sheet.
Pharmacology and toxicology
Tamoxifen is a steroidal anti-estrogen drugs. The structure similar to estrogen, Z type and E type two isomers. The different physical and chemical properties, physiological activity is different also, E have weak estrogen activity, Z has anti-estrogen role. If breast cancer cells with estrogen receptor (ER), estrogen, into the tumor cells, and its combination, prompting the DNA of tumor cells and the m - RNA synthesis, stimulate the growth of tumor cells. While taking tamoxifen in the Z isomer into cells, combined with ER competition, form a receptor complexes, its role in blocking estrogen, thereby inhibiting the proliferation of breast cancer cells.
[ indications ]
1. Treat women relapse metastasis of breast cancer.
2. Used to aid in the treatment of breast cancer after surgery, to prevent recurrence.
[ usage and dosage ]
Every 10 mg orally, 2 times a day, can also be 20 mg each time, 2 times a day.
Main ingredients: tamoxifen citrate. Its chemical name is: (Z) - N, N - dimethyl - 2 - [4 - (1, 2 - diphenyl - 1 - butylene) phenoxy] - ethylamine citrate salt.
[ properties ]
This product is a white sheet.
Pharmacology and toxicology
Tamoxifen is a steroidal anti-estrogen drugs. The structure similar to estrogen, Z type and E type two isomers. The different physical and chemical properties, physiological activity is different also, E have weak estrogen activity, Z has anti-estrogen role. If breast cancer cells with estrogen receptor (ER), estrogen, into the tumor cells, and its combination, prompting the DNA of tumor cells and the m - RNA synthesis, stimulate the growth of tumor cells. While taking tamoxifen in the Z isomer into cells, combined with ER competition, form a receptor complexes, its role in blocking estrogen, thereby inhibiting the proliferation of breast cancer cells.
[ indications ]
1. Treat women relapse metastasis of breast cancer.
2. Used to aid in the treatment of breast cancer after surgery, to prevent recurrence.
[ usage and dosage ]
Every 10 mg orally, 2 times a day, can also be 20 mg each time, 2 times a day.