[ composition ]
This article main ingredients for hydrochloric acid more gentle than the star, its chemical name: (8 s, 10 s) - 10 - (3 - amino - 2,3,6 - three out of hydroxy - * - L - suzhou - f pyranoside) acyl - 7-8 - ethanol, 8,9,10-4-6,8,11 - three hydroxyl hydrogen - 1 - methoxy - 5, 12 - naphthalate methadone hydrochloride.

[ properties ]
This product is a freeze-dried powder of orange and red. A bottle containing 10 mg more gentle than the star and a moderate amount of lactose and hydrochloric acid methyl p-hydroxybenzoate.

[Pharmacology and toxicology ]
Drugs may penetrate into the cells, combined with chromosome. Experiments have shown more gentle than star planar ring into the base pairs, thus forming complexes with DNA between seriously interfere with the DNA synthesis, synthetic DNA dependent RNA and protein synthesis. But through this mechanism to produce hyperplasia resistance than more gentle than star concentration needed for the clinical treatment of higher drug concentration in the tumor site. Recent experiments have shown drugs cause DNA topoisomerase II cracking of insert DNA, thus damage DNA tertiary structure. A role in the clinical treatment of drug concentration that is visible. More gentle than the star also related to the oxidation/reduction effect, a series of NADPH dependent cell reductase can restore more gentle than the star to half quinone free radicals, and then reacts with molecular oxygen high reactivity of cytotoxic compounds such as the activity of peroxides, hydroxyl and hydrogen peroxide, free radical formation and is related to the cytotoxic effect more gentle than the star. More gentle than the star role further parts may be in the cell membrane: combined with membrane lipid influences a variety of different functions. More gentle than star cytotoxic effects and/or fights hyperplasia could be the result of any of these mechanisms, there may be other mechanisms also exist. Research shows more gentle than star throughout the cell cycle were active role, including the period between the cells. So rapid hyperplasia tissue such as tumor tissues (but not including bone marrow, gastrointestinal tract and mucous membrane and hair follicles) is on the accreting more gentle than the star of the most sensitive.

[ indications ]
Mitosis and cytotoxic drugs. More gentle than the star can successfully induce a variety of malignant tumors, including acute leukemia, lymphoma, sarcoma of soft tissue and bone malignancies and solid tumors in adults and children, especially for breast cancer and lung cancer.

[ usage and dosage ]
Mixed liquids, vial contents dissolved in 5 ml water for injection or sodium chloride injection. After joining dissolved liquid, can jiggle small bottle and a half minutes to dissolve the contents, but don't reverse small bottle. Adults and children: [intravenous medication] : this is the most commonly used drug. After preparation of solution through the patency of the iv infusion, about 2 to 3 minutes. Can reduce thrombosis and so caused by drug spillover cellulitis and blisters, common solution of sodium chloride injection, 5% glucose injection, glucose and sodium chloride injection. Dose is usually based on body surface area is calculated. When adriamycin single usage, usually every three weeks, with 60-75 mg/m2, when repeated toxicity of antitumor agents share with other, more gentle than star dose should be reduced to every three weeks, with 30 to 40 mg/m2. If dose calculated according to weight, every three weeks, with 1.2 2.4 mg/kg single dose administration.