[ properties ]
This product is a pale orange slice

[Pharmacology and toxicology ]
Four hydrogen folic acid is the synthetic purine nucleotides and pyrimidine nucleotides of DNA in the body important coenzyme, this product as a kind of folic acid reductase inhibitors, the main inhibition dihydrofolate reductase and make dihydrofolate can't restore into folinic acid (a physiological activity, which makes a purine nucleotide and pyrimidine biosynthesis process carbon group blocked the transfer function of lead to the biosynthesis of DNA is addition, this product also has the inhibitory effect of thymus nucleotide synthetase, but the role of RNA and protein synthesis inhibition is weak, this article mainly ACTS on the S phase of cell cycle and cell cycle specificity of drugs, the G1 / S phase cells are slow, weak in G1 phase cells.

[ indications ]
1, various types of acute leukemia, especially acute lymphoblastic leukemia, malignant lymphoma, non-hodgkin's lymphoma and mycosis granuloma, multiple bone marrow disease;
2, head and neck cancer, lung cancer, all kinds of soft tissue sarcomas, psoriasis;
3, breast cancer, ovarian cancer, cervical cancer, malignant hydatidiform mole and chorionic carcinoma, testicular cancer.

[ usage and dosage ]
Once adult 5 mg to 10 mg orally, 1 times a day, 1 ~ 2 times per week, one period of treatment safe level 50 mg to 100 mg. Used for maintenance treatment of acute lymphocytic leukemia, a 15 to 20 mg mg/m2, once a week.