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Product Name:
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Rabbit Anti Human ATF4 PolyClonal Antibody
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Product Type :
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Rabbit Anti Human PolyClonal Antibody
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Code :
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CSB-PA002272KA01HU
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Size :
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100ul(100ug)
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Uniprot NO. :
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Immunogen :
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Recombinant protein of human ATF4
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Raised in :
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Rabbit
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Species Reactivity :
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Human+Mouse+Rat
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Tested Applications :
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WB: 1:500-1:2000 IHC: 1:50-1:200
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Relevance :
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ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen.
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Storage Buffer :
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Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purification method :
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Affinity purification
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Isotype :
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IgG
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Alias :
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ATF4;CREB-2;CREB2;TAXREB67;TXREB
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Species :
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Human
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Intended Use :
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For research use only. Not for human, diagnostic or therapeutic use.
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Target details :
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This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). This protein belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
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HGNC :
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RGD :
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MGI :
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BIOWWW :
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