Product Name: Dipyridamole
CAS NO: 58-32-2
Molecular Formula: C24H40N8O4
Formula Weight: 504.6256
Appearance: ellow crystalline powder
Assay: 99.0% min

Introduction

Dipyridamole is a PDE (phosphodiesterase) inhibitor with antioxidant properties. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis.
Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.
 
Application

1. Dipyridamole has been shown to lower pulmonary hypertension without significant drop of systemic blood pressure
2. It inhibits formation of pro-inflammatory cytokines (MCP-1, MMP-9) in vitro and results in reduction of hsCRP in patients.
3. It inhibits proliferation of smooth muscle cells in vivo and has shown to prevent AV-shunt failure in dialysis patients.
4. It increases the release of t-PA from brain microvascular endothelial cells
5. It results in an increase of 13 - HODE and decrease of 12-HETE in the subendothelial matrix (SEM) and reduced thrombogenicity of the SEM.
6. Pretreatment it reduced reperfusion injury in volunteers.
7. It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy.
8. It results in a reduction of the number of thrombin and PECAM-1 receptors on platelets in stroke patients.
9. cAMP impairs platelet aggregation and also causes arteriolar smooth muscle relaxation. Chronic therapy did not show significant drop of systemic blood pressure.
10. It inhibits the replication of mengovirus RNA.
 
Specification
 

Appearance	Yellow crystals or crystalline powder	Yellow crystalline powder
Solubility	Practically insoluble in water, freely soluble in acetone, soluble in  ethanol,  It dissolves in dilute solution of mineral acids.	Practically insoluble in water, freely soluble in acetone, soluble in  ethanol,  It dissolves in dilute solution of mineral acids.
IR-spectrum	Complies  with  reference  spectrum	Complies  with  reference  spectrum
Related  substances HPLC(Ph.Eur.2.2.29)	Total  impurities:not more  than 1.00%  Impurity A:not  more  than 0.50%  Impurity B:not  more  than 0.50%  Impurity C:not  more  than 0.50%  Impurity D:not  more  than 0.20%  Impurity E:not  more  than 0.20% Methyl 4- methyl benzenesulfonate: not more than 1 ppm	Total  impurities:0.70%  Impurity A:0.37%  Impurity B:0.14%  Impurity C:0. 02%  Impurity D:0.04%  Impurity E:0.02% Methyl4- methyl benzenesulfonate: Absence
GC(Ph.Eur.2.2.28)	Each other individual impurity:not more than0.10%	Each other individual impurity:not more than 0.10%
Chlorides	Not  more  than 200ppm	Not  more  than 200ppm
Loss  on  drying	Not  more  than  0.5%	0.05%
Sulphated  ash	Not  more  than  0.1%	0.06%
Assay	Between 98.5% and 101.5% Calculated on anhydrous  basis	99.2%
Bulk density	Not more 400ml/100g	286ml