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Product Name:
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Recombinant Rattus norvegicus (Rat) Transforming growth factor beta-1
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Product Type :
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Recombinant Protein
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Code :
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CSB-EP023446RA
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Size :
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1mg/500ug/200ug/50ug/10ug
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Uniprot NO. :
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Storage :
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Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
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Relevance :
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Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells
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References :
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"cDNA cloning by PCR of rat transforming growth factor beta-1." Qian S.W., Kondaiah P., Roberts A.B., Sporn M.B. Nucleic Acids Res. 18:3059-3059(1990)
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Storage Buffer :
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20mM Tris-HCl based buffer,pH8.0
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Alias :
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Cleaved into the following chain: Latency-associated peptide Short name: LAP
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Species :
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Rattus norvegicus (Rat)
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Purity :
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Greater than 90% as determined by SDS-PAGE.
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Sequence :
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LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRR
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Research Area :
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Signal Transduction
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Source :
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E.coli
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Gene Names :
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Tgfb1
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Expression Region :
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30-278aa
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Notes :
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Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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Product Info :
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His-SUMO-tag
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Mol. Weight :
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44.48kD
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Protein Description :
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Full length of Latency-associated peptide
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Link: w w w . cusabio . c o m
