Product Name:
Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit
Product Type : ELISA Kit
Code : CSB-EL015949HU
Size : 96T,5×96T,10×96T
Uniprot NO. : P46531
Abbreviation : NOTCH1
Protein Biological Process 1 : Developmental Protein
Alias : TAN1, hN1, neurogenic locus notch homolog protein 1|notch1|translocation-associated notch protein TAN-1
Species : Human
Protein Biological Process 3 : Differentiation
Sample Types : serum, plasma, tissue homogenates, cell lysates
Detect Range : 15.6 pg/ml-1000 pg/ml
Sensitivity : 3.9 pg/ml
Assay Time : 1-5h
Sample Volume : 50-100ul
Detection Wavelengt : 450 nm
Availability : 5-7 working days
Research Area : Developmental Biology
Protocol :
 Instructions
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target details : This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.