Product Name: Obeticholic Acid CAS: 459789-99-2
Synonyms: 6-Ethylchenodeoxycholic acid; 6alpha-Ethyl-chenodeoxycholic acid; 6-Ecdca; 6-Ethyl-cdca; C15636;6-Ethylchenodeoxycholic acid(Obeticholic Acid); Obeticholic Acid; (3α, 5β, 6α, 7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid
CAS: 459789-99-2
MF: C26H44O4
MW: 420.63
density 1.091
Appearance : White powders
Purity : 99%
Package : 1kg/foil bag
Related categories: pharmaceutical intermediates; pharmaceutical raw materials; Aobei acid; API
Usage : Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM.


In vitro:

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM.

In vivo:

In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p. o. ) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p. o. ) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension.


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