| Purity: | 99% |
|---|---|
| Brand Name: | NJBN STEROID |
| Grade Standard: | Medicine Grade |
| Place of Origin: | China (Mainland) |
| EINECS No.: | 227-069-1 |
| MF: | C21H28O2 |
| Other Names: | TIBOLONE |
| CAS No.: | 5630-53-5 |
| LIVIELLA: | LIVIAL |
Quick Details
Specifications
Effective 99% Synthetic Steroid CAS 5630-53-5 Livial for Female Menopausal Syndrome Treatment
Tibolones Acetate
SPECIFICATION
RESULTS
Description
: White Or Almost White Crystalline Powder
White Powder
Identification
: Infrared Absorption
Positive
Assay
: 97.0~103.0%
99.15%
Melting Point
: 33~37°C
34.5~36.5°C
Loss On Drying
: 0.5%max
0.30%
Specific Rotation
: +32°~ +36°(C=1 in dioxane)
+33.5°
Organic Volatile Impurities
: 2500PPm max
<1000PPm
Residual Solvents
: Meet the requirements.(USP29)
Confirms
Chromatographic purity
: sum of impurities:3.0%max
<3.0%
Conclusion
The specification conform with USP32 standard
1. Quick Detail of Livial
Product name:
Livial
Other Name
Tibofem;
Original
China
CAS
5630-53-5
Molecular formula
C21H28O2
Molecular weight
312.45
Brand name
NJBNSteroid
Delivery time
within 24 hours upon receipt of payment
Delivery
Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity
99%
Package
Discreet and Hidden package according to specific requirement
Appearance
White powder
Certification
SGS, ISO 9001, KOSHER
Payment Terms
Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity
10 g
Price
Negotiable
Usage
pharmaceutical material, Steroid hormone, Anabolin. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
2. Overview of Livial
Livial (INN, USAN, BAN) (brand name Livial, Tibofem), also known as 7alpha-methylnoretynodrel, is a synthetic steroid drug with estrogenic, progestogenic, and weak androgenic actions which was introduced in 1988 and is used widely in Europe, Asia,Australasia, and, with the exception of the United States (where it is not available), the rest of the world.
It is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.
Livial is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. It is used mainly for treatment of endometriosis,as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile.It has also been investigated as a possible treatment for female sexual dysfunction.
3. Clinical Application of Livial
Livial is a synthetic molecule used extensively for the management of menopausal symptoms, with the proposed additional advantage of enhanced mood and libido. Livial , after oral administration, is rapidly converted into 3 major metabolites: 3alpha-hydroxytibolone and 3beta-hydroxytibolone, which have estrogenic effects and has progestogenic and androgenic effects. The tissue-selective effects of tibolone are the result of metabolism, of enzyme regulation, and of receptor activation which vary in different tissues.
Tibolone seems to be effective on estrogen-withdrawal symptoms such as hot flushes, sweating, insomnia, headache, and vaginal dryness, with results generally comparable to the effects exerted by estrogen-based treatments, and the additional property of a progestogenic activity on the endometrium. As well as relieving vasomotor symptoms, tibolone has positive effects on sexual well-being and mood, and improves dyspareunia and libido.
4. COA
Application:
Tibolone is a synthetic molecule used extensively for the management of menopausal symptoms, with the proposed additional advantage of enhanced mood and libido. Tibolone, after oral administration, is rapidly converted into 3 major metabolites: 3alpha-hydroxytibolone and 3beta-hydroxytibolone, which have estrogenic effects and has progestogenic and androgenic effects. The tissue-selective effects of tibolone are the result of metabolism, of enzyme regulation, and of receptor activation which vary in different tissues.
Tibolone seems to be effective on estrogen-withdrawal symptoms such as hot flushes, sweating, insomnia, headache, and vaginal dryness, with results generally comparable to the effects exerted by estrogen-based treatments, and the additional property of a progestogenic activity on the endometrium. As well as relieving vasomotor symptoms, tibolone has positive effects on sexual well-being and mood, and improves dyspareunia and libido.