99% PDE5 inhibitor Medical Material CAS 171596-29-5 Tadalafil for Erectile dysfunction

1.Quick Detail of Tadalafil

Product name:	Tadalafil
Other Name	TADALAFIL;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;
Original	China
CAS	171596-29-5
Molecular formula	C22H19N3O4
Brand name	NJBNSteroid
Delivery time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	White Crystalline Powder
Certification	SGS, ISO 9001
Payment Terms	Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10 g
Price	Negotiable
Usage	Erectile-dysfunction Treatmnt

Description

Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under  name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Tadalafil for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide.

It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialistablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20-mg tablets) once daily.

Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10 mg and 20 mg.

Usage of Tadalafil:
 
1.Tadalafil, is an orally administrated drug developed by the pharmaceutical company Eli Lily for treatment of male erectile dysfunction disease. It belongs to the second generation of phosphodiesterase type 5 inhibitors. Study has shown that compared with sildenafil, the onset rate of Tadalafil is very rapid with about 15 ~ 20 min for onset and with long-term effects up to 36h. Its T1/2 was 17.5h.

2.It is a kind of PDE-5 inhibitors which can be used for the treatment of male erectile dysfunction. It is also the second generation of phosphodiesterase type 5 inhibitors used to treat male erectile dysfunction

a study including 348 cases of patients with mild to severe erectile dysfunction, male patients were randomized for being subject to 20 mg of tadalafil or placebo. The results have showed that, compared with placebo, the intercourse success rate at 24 and 36 hours after taking the drug are both improved with most male patients can successfully have sexual intercourse for twice within 36 hours. There is also no difference in the incidence and severity of the adverse drug reactions compared with placebo. In the tadalafil group, more than 5% of men get headache and indigestion. 

Note:

In a study including 348 cases of patients with mild to severe erectile dysfunction, male patients were randomized for being subject to 20 mg of tadalafil or placebo. The results have showed that, compared with placebo, the intercourse success rate at 24 and 36 hours after taking the drug are both improved with most male patients can successfully have sexual intercourse for twice within 36 hours.

Technical Test Sheet

Test	Specifications	Result
Assay by HPLC:	99%	99.61%
Appearance	White fine powder	Complies
Odor & taste:	No odor	Complies
Mesh size:	100% pass 80mesh 100mesh	Complies
Solubility:	Insoluble in water & ethanol	Complies
Loss on drying:	≤2.0%	1.1%
Heavy metals PPM:	<20ppm	Complies
Microbiology: Total Plate Count: Yeast & Mold: E.Coli: S. Aureus: Salmonella:	<1000cfu/g <100cfu/g Negative Negative Negative	600cfu/g 80cfu/g Complies Complies Complies

Adverse reaction:

it has no serious adverse reactions. No adverse reactions such as facial flushing, vision abnormalities after serving have been observed. There has been occasionally headache and indigestion.

Note :for patients serving nitrates, angina, heart disease, uncontrolled hypertension or hypotension. Patients who had got stroke within the past six months should be disabled.