Finasteride

English Synonyms: PROSCAR; PROSTIDE; N-(2-METHYL-2-PROPYL)-3-OXO-4-AZA-5ALPHA-ANDROST-1-ENE-17BETA-CARBOXAMIDE; MK-906; (5alpha, 17beta)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; 17beta-(n-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one; 4-azaandrost-1-ene-17-carboxamide, n-(1,1-dimethylethyl)-3-oxo-, (5-alpha, 17-be; 4-azaandrost-1-ene-17-carboxamide, n-(1,1-dimethylethyl)-3-oxo-, (5alpha, 17beta

CAS NO. : 98319-26-7

Assay: 99%

Molecular Formula: C23H36N2O2

Molecular Weight: 372.54

Packing: foil bag

Appearance: White or white crystalline solid. Soluble in chloroform, dimethyl sulfoxide, ethanol, methanol or propanol, insoluble in propylene glycol or polyethylene glycol 400

Usage: The drug can be very effective in reducing blood and dihydro testosterone within the prostate. Finasteride no affinity to the androgen receptor

2. Description:

Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). It is a type IIand type III5alpha-reductase inhibitor; 5 alpha-reductase, an enzyme, convertstestosterone to dihydrotestosterone (DHT).

3. Medical Uses

(1) Benign prostatic hyperplasia

Physicians use finasteride for the treatment of BPH, informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow.

(2) Male pattern baldness

Finasteride is used to treat male pattern hair loss (androgenetic alopecia) in men only. Treatment provides about 30% improvement in hair loss after six months of treatment, and effectiveness only persists as long as the drug is taken.

(3) Off-label uses

Finasteride is sometimes used in hormone replacement therapy for male-to-female transsexuals in combination with a form of estrogen due to itsantiandrogen properties. However, little clinical research of finasteride use for this purpose has been conducted and evidence of efficacy is limited.

3. Technical Test Sheet

Test Items	Specification		Test Results
Description	White or off-white crystalline powder		Off-white crystalline powder
Specific rotation	-56°~-60°		-58.2°
Identification	IR	Matches with working standard	Complies
	HPLC
Solubility	Freely soluble in chloroform and in alcohol; Very slightly soluble in water		Conform
Heavy metals	≤10ppm		< 10ppm
Water	≤0.3%		0.22%
Residue on ignition	≤0.1%		0.05%
Relative material	single impurity≤0.5%		0.36%
	Total impurity≤1.0%		0.52%
Assay	98.5~101.0%		99.48%

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