Tacrolimus
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
mp 113-115°C
storage temp. ? 20°C
solubility DMSO: > 3 mg/mL
Chemical Properties White Crystalline Solid
Usage An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum

Product name:	Tacrolimus
Other Name	(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
Original	China
CAS	104987-11-3
Molecular formula	C44H69NO12
Molecular Weight	804.02
Brand name	NJBNSteroid
Delivery time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	Whire Powder
Certification	SGS, ISO 9001, KOSHER
Payment Terms	Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10 g
Price	Negotiable
Usage	Used as immunosuppressant.

Description  
 
Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly afterallogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, amolecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease,Kimura's disease, and the skin condition vitiligo.

Clinical Function:

It is taken as an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.

Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.

It is for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.

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