Axitinib Active Pharmaceutical Ingredients 319460-85-0 For Cancer Therapy

 

Axitinib Basic Information:

Product name: Axitinib

CAS: 319460-85-0

MF: C22H18N4OS

MW: 386.47

Purity: 99%

Appearance: White to off-White Powder

Chemical Properties Off-White Solid
Usage Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

 

Axitinib Description :

 

• Axitinib is also called by its brand name Inlyta. It is a type of drug called a tyrosine kinase inhibitor, which is a cancer growth blocker. It blocks certain proteins called tyrosine kinases from acting on cells. Tyrosine kinases signal to cancer cells to grow.
• Axitinib blocks different types of tyrosine kinase and is called a multi kinase inhibitor. It stops cancer cells forming blood vessels, which the cancer needs in order to grow. This is called anti angiogenesis treatment.
• Axitinib is a treatment for advanced kidney cancer. You may also have it as part of a clinical trial for other cancers including soft tissue sarcoma and thyroid cancer.

 

Axitinib COA:

 

Items of analysis	Specification	Results
Description	off-white powder	Conforms
Loss on drying	NMT 1.0%	0.7%
Water content	NMT 0.5%	0.13%
Single impurity	NMT0.1%	0.07%
Total impurity	NMT 0.5%	0.29%
Purity(HPLC)	NLT 99.0%	99.71%
Conclusion	Qualified

 

 

 

 

 

 

 

 

 

 

Axitinib Usage :

 

Axitinib is a small molecule tyrosine kinase inhibitor developed . It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models and has shown partial responses in clinical trials with renal cell carcinoma (RCC) and several other tumour types. It has been shown to significantly Inhibit growth of breast cancer in xenograft models and has been successful in trials with renal cell carcinoma (RCC) and several other tumor types.