| Appearance: | White crystal powder |
|---|---|
| Application: | pharmaceutival material |
| Model Number: | 104632-26-0 |
| Purity: | 99% |
| Type: | Pharmaceutical Intermediates |
| Place of Origin: | China (Mainland) |
| MF: | C10H17N3S |
| CAS No.: | 104632-26-0 |
Quick Details
Specifications
Pramipexole CAS 104632-26-0
Synonyms: Mirapex, Mirapexin, Sifrol;
CAS Number: 104632-26-0
Molecular Weight: 211.324 g/mol
Molecular Formula: C10H17N3S
Appearance: white crystalline powder
Description
Pramipexole (Mirapex, Mirapexin, Sifrol) is a dopamine agonist of the non-ergoline class indicated for treatingParkinson's disease (PD) and restless legs syndrome (RLS).
Pramipexole is the generic name for the prescription drug Mirapex, which is used to treat symptoms of Parkinson's disease and restless leg syndrome (RLS).
Mirapex belongs to a class of drugs called dopamine agonists. Scientists believe that it encourages dopamine activity in the body by increasing the sensitivity of dopamine receptors.
In the brain, dopamine acts as a neurotransmitter — helping nerves communicate — which improves movement in restless leg syndrome and helps relax tremors in Parkinson's disease.
Originally manufactured by Boehringer Ingelheim under the brand name Mirapex, pramipexole was first approved by the Food and Drug Administration (FDA) in 1997.
Medical Uses:
Treating the signs and symptoms of Parkinson disease. It is also used to treat restless legs syndrome (RLS). It may also be used for other conditions as determined by your doctor.
Pramipexole is a dopamine agonist. Exactly how pramipexole works is not known. It may increase the action of certain chemical receptors in the brain.
Parkinson's disease is a neurodegenerative disease affecting the substantia nigra, a component of the basal ganglia. The substantia nigra has a high quantity of dopaminergicneurons, which are nervecells that release the neurotransmitterknown as dopamine. When dopamine is released, it may activate dopamine receptors in the striatum, which is another component of the basal ganglia. When neurons of the substantia nigra deteriorate in Parkinson's disease, the striatum no longer properly receives dopamine signals. As a result, the basal ganglia can no longer regulate body movement effectively and motor function becomes impaired. By acting as an agonist for the D2, D3, and D4 dopamine receptors, pramipexole may directly stimulate the underfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia.
Dosage:
Pramipexole is found in tablet form and is taken orally. The drug's half-life is approximately 8-12 hours in duration. It is most commonly found in 0.125mg, 0.25mg, 0.5mg, 0.75mg, 1mg and 1.5mg strengths. For the treatment of Parkinson's you will find dosing is somewhat heavy compared to other issues of treatment. Doses for Parkinson's treatment normally start low in order to allow the body to accustom starting at 0.125mg 2-3 times per day and increases gradually over several weeks reaching anywhere from 0.75-1.5mg 2-3 times per day depending on need.
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Specification:
|
TEST ITEMS |
SPECIFICATION |
RESULTS |
|
Description |
: White Crystalline Powder |
White Powder |
|
Identification |
: Positive |
Positive |
|
Assay(by HPLC) |
: 98.0~102.0% |
98.64% |
|
Absorbance(E1cm) |
: 465~495 |
482.5 |
|
Melting Point |
: 191~195°C |
193.5~195.0°C |
|
Loss On Drying |
: 0.5%max |
0.19% |
|
Specific Rotation |
: +288°~ +298° |
+290.2° |
|
Residue On Ignition |
: 0.1%max |
0.03% |
|
Related Substances |
: Total: 1.5%max |
< 1.3% |
|
Single: 0.5%max |
< 0.4% |
|
|
Residue Solvents |
: 0.2%max |
0.10% |
|
Heavy Metals |
: 20PPm max |
< 10PPm |
|
Conclusion |
The specification conform with enterprise standard. |
|
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