Oxytocin CAS 50-56-6 

Basic Details:
Product Name: Oxytocin
Synonyms: A-HYPOPHAMINE
CAS:    50-56-6
MF:    C43H66N12O12S2
MW:    1007.19
EINECS:    200-048-4
Purity (HPLC): 98.0%min.
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤6.0%
Acetate Content(HPIC): ≤12.0%
MP:  192-194 °C
BP:  1533.3°C at 760 mmHg
FP:  881.1°C
Storage temp:  2-8°C
Appearance: white powder
Density: 1.27 g/cm3

Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.

Usage : Common used with ergot preparations, treatment for postpartum hemorrhage; Inevitable abortion; Mainly used in late pregnancy induced labor and intrapartum uterine contractions fatigue caused by prolonged labor; Used for oxytocin sensitive test; Used for oxytocin irritability test; 

1.  Description

Oxytocin is also called Pitocin, is a kind of uterine contraction medicine, can be extracted from animal posterior pituitary or chemical synthesis, chemical synthesis including on vasopressin, no booster effect, selective excitate uterine smooth muscle, strengthen its contracting, uterus is most sensitive to oxytocin (estrogen secretion increase) when parturient,  immature uterus have no reactivity to this product, pregnancy early or middle uterine have low reactivity to oxytocin, late pregnancy is gradually increased, and before the antepartum, the reactivity is the highest.

How to Use?

Oral invalid, easily destroyed by digestive juice, but can be oral cavity mucous membrane absorption, intravenous drip 0.01 IU can cause uterine physiological contraction in 1 ~ 3 minutes (rhythmicity, polarity, symmetry), hold time is short, the half-life is only 2.5 ~ 3 minutes high-dose make uterine muscle is tetanic contraction. Have synergy effect with prostaglandin.

Medical Function:

Small dose can strengthen the smooth muscle contraction rhythm at the bottom of the uterine, to reinforce the contraction force, contraction frequency, shrinkage properties similar to those in natural birth, and keep the polarity and symmetry, so the clinical used in hastening parturition, inducing abortion. Large dose make uterine muscle tetanic contraction, clinical to oppression blood vessels between muscle fibers, to prevent and treatment of postpartum hemorrhage and postpartum subinvolution, and has the effect to promote lactation, the breast duct contraction, prompting milk from the breast. Larger dose is also used in postpartum hemorrhage, the afterbirth not out, etc.

In recent years, it is found that this product has good effect on pulmonary hemoptysis, and vagus nerve after resection or relaxation of gastrointestinal function after abdominal surgery. 

This product can absorb from the oral mucosa, and selectively acts on the smooth muscle of the uterus, make uterine contractions. Apply to hastening parturition and slow painful. Effect is the same as the static drops of oxytocin. For contracted pelvis, has a history of uterine surgery (including cesarean section), pain excessive hyperfunction, birth canal obstruction, severe placental abruption, maternal pregnancy poisoning are prohibited. 
Uterine contractions. Used for induced labor, oxytocin, postpartum and abortion after uterine bleeding caused by contractions weak and so on. Intranasal can make milk.

TTS

Item	Quality standard	Result
Assay	93.0~102.0%	99.08%
Solubility	Soluble in water or 1% acetic acid at a concentration of ≥1mg/ml to give a clear, colorless solution	Confirm
Identification by HPLC	The retention is same with the reference substance	Conforms
	Asp: 0.90~1.10	0.95
	Glu: 0.90~1.10	1.02
	Pro: 0.90~1.10	1.04
Amino Acid Composition	Gly: 0.90~1.10	1.01
	Leu: 0.90~1.10	1.00
	Leu: 0.90~1.10	0.98
	Tyr: 0.70~1.05	0.96
	Cys:1.40~2.10	1.85
PH	3.0~6.0	4.8
Specific Optical Rotation	C=1,1%HAc	-20.97°
Peptide Purity (HPLC)	≥ 95.0%	99.13%
Related Substances (HPLC)	Total Impurities(%)≤ 5.0% Largest Single impurity(%)≤ 1.5%	0.87% 0.35%
Acetic Acid (HPLC)	6~10%	9.56%
Water Content (Karl Fischer)	≤5.0%	2.38%
Bacterial Endotoxins	≤300 IU/mg	Conforms
Colour of solution	colorless	colorless
Activity	A) 1mg of Oxytocin peptide is equivalent 600IU B) >=480IU/mg	600.1 IU(Net) 528.1 IU(Wt)
Description	White powder
Conclusion: the product is in conformity with EP6.0/USP3.2.

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