Effective Top Purity 136-47-0 Local Anesthetics Drugs Anodyne Tetracaine Hydrochloride For Pain Relief


Quick Detail :

Product Name:	Tetracaine hydrochloride
Synonyms:	L AND OCAIN HYDROCHLORIDE; INTERCAIN HYDROCHLORIDE; MEETHOBALM HYDROCHLORIDE; 2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE; 2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE; 4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO) ETHYL ESTER HYDROCHLORIDE; 4-[BUTYLAMINO]BENZOIC ACID-2- [DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE; 4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL
CAS:	136-47-0
MF:	C15H25ClN2O2
MW:	300.82
EINECS:	205-248-5
Product Categories:	API intermediates; Sodium channel; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Pharmaceutical intermediate; PONTOCAINE; Local anesthetic
Usage	A local anesthetic used topically in opthalmology.
Chemical	White Solid

Description :

Tetracaine hydrochloride is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Application :

Tetracaine hydrochloride (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

Tetracaine hydrochloride, In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

COA :

Test Items	Specification	Test Results
Appearance	Fine, white, crystalline, odorless powder	confirm
Identification	ABC in Pass	confirm
Solubility	Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene	confirm
USP Reference standards	USP Tetracaine Hydrochloride RS. USP Endotoxin RS.	Confirm
Melting point	145~150 degree	146.0~147.5 degree
Chromatographic purity	In Pass	confirm
Related substance	Not more than the reference solution 0.05%	confirm
Heavy metals	≤10ppm	confirm
PH	4.5-6.5	5.8
Residue on ignition	≤0.10%	0.05%
Loss on Drying	≤ 0.5%	0.19%
Assay	98.0 -101.0%	100.1%
Conclusion	Confirms USP 32

Local anesthetics:

Benzocaine CAS: 94-09-7
Benzocaine hydrochloride CAS: 23239-88-5
Tetracaine hydrochloride CAS: 136-47-0
Procaine CAS: 59-46-1
Tetracaine CAS: 94-24-6
Pramoxine Hydrochloride CAS: 637-58-1
Procaine HCl CAS: 51-05-8
Lidocaine CAS: 137-58-6
Dibucaine hydrochloride CAS: 61-12-1
Prilocaine CAS: 721-50-6
Propitocaine hydrochloride CAS: 1786-81-8
Proparacaine hydrochloride CAS: 5875-06-9
Lidocaine hydrochloride CAS: 73-78-9
Articaine hydrochloride CAS: 23964-57-0
Levobupivacaine hydrochloride CAS: 27262-48-2

Ropivacaine hydrochloride CAS: 132112-35-7
Bupivacaine CAS: 2180-92-9
Bupivacaine hydrochloride CAS: 14252-80-3