Mometasone furoate CAS 83919-23-7 for anti-inflammatory

1. Mometasone furoate

English Synonyms: SCH-32088;MOMETASONE 17-FUROATE;MOMETASONE FUROATE;NASONEX;(11-beta,16-alpha)-xy-16-methyl;pregna-1,4-diene-3,20-dione,9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydro;9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate;(11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCARBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE

CAS NO.: 83919-23-7

Assay: 98%

Molecular Formula: C32H32Cl2O8

Molecular Weight:615.5

Packing:foil bag

Usage: The effect of topical corticosteroids, have anti-inflammatory, antipruritic and vasoconstrictor effects. For skin disease patients, can relieve inflammation and itching, particularly the use of cortisone in patients.

2. Description:

Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form mometasone (INN).

3. Medical Uses:

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) or patients unresponsive to less potent corticosteroids, and penile phimosis.In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.

Mometasone is indicated for the alleviation of inflammatory and pruritic manifestations (with stinging and itching) of dermatosis which respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis (affection dermic chronic, characterized by the apparition of squamous eruptions, accompanied by itching).

Nasal mometasone is employed in adults (including the elderly) and children over 2 years, diminishing the symptoms such as hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, and sneezing. It can be used two to four weeks before pollen season, reducing the severity of symptoms. It is also indicated for the treatment of nasal polyps and symptoms associated with including congestion and hyposmia in patients over the age of 18. It can also produce nasal drip, a sensation of tickling in the throat, and loss of the sense of taste and smell.

4. Technical Test Sheet.

Test Item	Standard	Test Result
Appearance	white crystal or powder	white crystal or powder
Identification	infra-red spectrum	accord with normal frequency spectrum
Specific rotation	+56°C-+62°C	+60.56°C
Drying Loss	≤0.5%	0.27%
Residue on Ignition	≤0.1%	0.08%
Heavy metal	≤30ppm	18ppm
Assay	97.0%-103.0%	98.2%

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