Fluocinolone acetonide CAS 67-73-2 for Treatment of Eczema

(6-alpha,11-beta,16-alpha)-idene)bis(oxy));(6alpha,11beta,16alpha)-idene)bis(oxy));20-dione,6,9-difluoro-11,12-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-,(6-alpha,11-bpregna-4-diene-3;6-alpha,9-alpha-difluoro-16-alpha-hydroxyprednisolone16,17-acetonide;6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone16,17-acetonide;dermalar;fluocinolone16,17-acetonide;Fluocinoloneacetate

CAS NO.:67-73-2

Assay: 98%

Molecular Formula: C24H30F2O6

EINECS: 200-668-5

Molecular Weight: 452.49 

Packing:foil bag

Usage: It is suitable in the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, dermatitis and other diseases.

1.  Description:

Fluocinolone acetonide is a kind of topical corticosteroids of the most significant effect and the least side effect , and can cause the contraction of dermal capillary, inhibit cell proliferation or regeneration of connective tissue; it can also stabilize the intracellular lysosomal membrane and prevent the release of histamine from the intracellular lysosomal enzyme and the further tissue damage. The anti-inflammatory effects of Fluocinolone is 100 times as great s that of hydrocortisone. It has significant efficacy even at the lowest concentration (0.025%) with rapid onset rate and can significantly reduce or cure the symptoms in a few days with a relative excellent itching relief effect.

Fluocinolone acetonide is suitable for treating the skin disease to which corticosteroid is effective skin such as eczema (especially eczema), neurodermatitis, skin pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, and solar dermatitis. 

Medical Uses:

Fluocinolone acetonide is a synthetic, fluorine-containing potent steroid. Topical administration of it can cause dermal capillary contraction and can inhibit epidermal cell proliferation or regeneration, inhibit the newborn of the fibroblast cells inside the connective tissue and stabilize the intracellular lysosomal membrane with anti-inflammatory and anti-itching effect. 

 Fluocinolone acetonide is mainly used for the treatment of skin diseases to which glucocorticoid is effective such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, dermatitis, eczema (especially infant eczema), pruritus disease, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa and so on. Its combination with neomycin and other antibiotics can be used for the treatment of suppurative skin disease.

Apply 0.025-0.05% ointment, lotion for scrubbing the affected area with 2-3 times per day. You can gently knead and make it be incorporated into the skin.

Technical Test Sheet

Anti Estrogen Steroids Fluocinolonetonide 67 - 73 - 2 As Anti - Inflammatory skype: jerryzhang20161
Product name	Fluocinolone acetonide
CAS No.	67-73-2	Outer Packing	1KG aluminum foil bag
Production date	2016.07.11	Shelf life	2020.07.09
Standard adopted	USP32
Items of analysis	Specification		Results
Descriptiom	White or almost white crystalline power		white crystalline power
Specific Rotation	+98°~ +108°		+102.30°
Identification	(1) IR (2) TLC		Meets The Requirements
Any impurity	≤1.0%		0.60%
Only one impurity	0.50%≤Only one impurity≤1.0%		Meets The Requirements
Total impurity	≤2.0%		1.69%
Loss On Drying	≤1.0%		0.78%
Assay	97.0%~102.0%		98.4%
Partical Size	90%≤45um		90%≤45um
Conclusion	Qualified

Chemical Property

It appears as white or white-like crystalline powder and is odorless and tasteless. It is soluble in acetone, slightly soluble in ethanol, dioxane but insoluble in water and petroleum ether. It is obtained through the sulfonic esterfication, ring-opening reaction and further 16-steps reactions starting from the 11 alpha- hydroxy -16alpha, 17alpha- epoxy pregnane-4-ene-3, 20-dione. It can be applied to atopic dermatitis, contact dermatitis, eczema and other skin diseases.

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