TELMISARTAN
CAS: 144701-48-4
MF: C33H30N4O2
MW: 514.63
mp 261-263°C
density 1.16
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: > 5 mg/mL at 60 °C
Water Solubility insoluble
Chemical Properties White or off white crystalline powder
Usage An angiotensin II receptor antagonist
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum

Product name:	Telmisartan
Other Name	naphconforte; naphthasoliumchloride; niazol; privinehydrochloride; prizolehydrochloride; rhinantin; rhinoperd; sanorin-spofa
Original	China
CAS	144701-48-4
Molecular formula	C33H30N4O2
Molecular Weight	514.63
Brand name	NJBNSteroid
Delivery time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	white crystalline powder
Certification	SGS, ISO 9001, KOSHER
Payment Terms	Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10 g
Price	Negotiable
Usage	essential hypertension treatment

Description

Telmisartan is a novel type of blood pressure lowering drug and is a kind of specific antagonist for the angiotensin II receptor (AT I type) antagonist for the treatment of essential hypertension, replacing the angiotensin II receptor for binding with the AT I receptor subtypes (known action sites of angiotensin II) with high affinity. Telmisartan has no site agonist effect on the AT I receptor and selectively binds with the AT I receptors with a long-lasting binding effect. It has no affinity to other receptors (including AT2 and other less characterized AT receptors).

Clinical efficacy and characteristics:

1, Pharmacokinetic exhibits that: fast-action (0.3h), long duration (35.4h), small effect on the heart rate during blood pressure lowering.
2 Comparison with enalapril: its antihypertensive effect is better than enalapril; even when both of them are used in combination with diuretics, Telmisartan still has a better effect with a lower incidence of cough.
3. Comparison with lisinopril: the antihypertensive (systolic and diastolic) effect is more significant; the incidence of cough in the telmisartan group (16%) was significantly lower than that in the lisinopril group (60%)
4, Comparison with atenolol: it has a comparable antihypertensive with the incidence of the adverse reaction (impotence and fatigue) being lower.
5, compared with amlodipine: telmisartan group can significantly reduce the heart rate within four hours after taking the drugs and from 6' clock to 12' clock in the short, compared with other classes of antihypertensive drugs, telmisartan has the following characteristics: having specificity of the receptors action; significant antihypertensive effect; remarkable diuretic effect; can improve cardiac stenosis disorder; safe drug; excellent tolerability; Take one time per day; it is easy to take.

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