Effective 99% local-Anesthetic 2180-92-9 Reduce Pain Marcaine Bupivacaine


Bupivacainep Basic Information

 

Name	Bupivacaine
CAS	2180-92-9
Assays	99%
MF	C18H28N2O
MW	288.43
Appearance	White crystal
Minimum Order Quantity	10 grams
Categories	Active Pharmaceutical Ingredients
Appearance	White powder
Usage	local (in only one area) anesthetic.

Bupivacainep Medical usages

Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. It is sometimes used in combination with epinephrine to prevent systemic absorption and extend the duration of action. The 0.75% (most concentrated) formulation is used in retrobulbar block. It is the most commonly used local anesthetic in epidural anesthesia during labor, as well as in postoperative pain management.

Bupivacainep Contraindications

Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. It is also contraindicated in obstetrical paracervical blocks and intravenous regional anaesthesia (Bier block) because of potential risk of tourniquet failure and systemic absorption of the drug and subsequent cardiac arrest. The 0.75% formulation is contraindicated in epidural anesthesia during labor because of the association with refractory cardiac arrest.

Bupivacainep Side effects
 

• Bupivacainep,Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. However, adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs are caused by accelerated absorption from the injection site, unintentional intravascular injection, or slow metabolic degradation. However, allergic reactions can rarely occur.

 

• Bupivacainep,Clinically significant adverse events result from systemic absorption of bupivacaine and primarily involve the central nervous system (CNS) and cardiovascular system. CNS effects typically occur at lower blood plasma concentrations. Initially, cortical inhibitory pathways are selectively inhibited, causing symptoms of neuronal excitation. At higher plasma concentrations, both inhibitory and excitatory pathways are inhibited, causing CNS depression and potentially coma. Higher plasma concentrations also lead to cardiovascular effects, though cardiovascular collapse may also occur with low concentrations. Adverse CNS effects may indicate impending cardiotoxicity and should be carefully monitored.

Order Process And Tips

 

Make an order	Please make clear what product and what quantity you need
Mini Order	100g, negotiable
Quote	Prices and Specification details(COA) would be offered for you to consider and confirm
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Delivery ways	All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping address	Provide your Valid and Correct destination address info(if possible with post code, phone number).
Packing	Select best ways according to quantity and safety degree(Super discreet, professional and experienced)
Lead time	Within 12 hours upon receipt of payment
Package pictures	Photos of parcel would be offered to tell apart the items
Tracking number	Offered once it is released
Shipping time	3-7 working days (Door-to-Door)
After-sale service	24/7 Online for any problems

Bupivacainep Mechanism of action

Bupivacaine binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur.
Pharmacokinetics.

Bupivacaine,Onset of action (route and dose-dependent): 1-17 min.Duration of action (route and dose-dependent): 2-9 hr.Half life: neonates, 8.1 hr, adults: 2.7 hr.Time to peak plasma concentration (for peripheral, epidural or caudal block): 30-45 min.Protein binding: about 95%.Metabolism: hepatic.Excretion: renal (6% unchanged).Chemical skeleton

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