Cilostazol
CAS: 73963-72-1
MF: C20H27N5O2
MW: 369.46
mp 159-160°C
storage temp. Store at RT
solubility DMSO: 18 mg/mL, soluble
Chemical Properties Colourless Needles
Usage A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum

Product name:	Cilostazol
Other Name	6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY]-3,4-DIHYDRO-2(1H)-QUINOLINONE; 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1h)-quinolinone additional name: 6-[4-(1-cyclohexyl-5-tetrazolyl)butoxy]-1,2,3,4- tetrahydro-2-oxoquinolinone; CILASTAZOL; CILOSTAZOL; CILOSTAZOLE; RETAL; OPC 13013; OPC 21
Original	China
CAS	73963-72-1
Molecular formula	C20H27N5O2
Brand name	NJBNSteroid
Delivery time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	White Powder
Certification	SGS, ISO 9001
Payment Terms	Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10 g
Price	Negotiable
Usage	Cilostazol is commonly used clinically anti-platelet and anti-clotting drug

Introduction and Usage of Cilostazol:

1. Cilostazol is commonly used clinically anti-platelet and anti-clotting drugs. It belongs to a phosphodiesterase inhibitor and can inhibit the activity of phosphodiesterase of platelet and smooth muscle cells, leading to increase of the cAMP concentration in platelets and vascular smooth muscle.

2. It can significantly inhibit the platelet aggregation induced by various kinds of aggregation inducers, and can cause the dissociation of the aggregates. Its major metabolite, epoxide has a three to four fold activity of the prototype drug.

3. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate. Artery injection of this product can increase the blood flow rate with the strongest effect on the peripheral blood vessels but the weakest effect on the cerebral blood vessels.

4. This product is rapidly absorbed in the intestine after oral administration with the Tmax being 3h, PPB being about 95%. Consecutive administration of four days by twice per day caused no increase in the plasma concentration accumulation. It has good tissue distribution with especially high level in the stomach, liver and kidney.

Application of Cilostazol:

1. It can be used to alleviate the ischemic symptom such as ulcers, limb pain, cold sensation and intermittent claudication caused by chronic arterial occlusive disease.

2. It can also be applied to the adjuvant treatment of atherosclerosis, arteritis, thromboangiitis obliterans, diabetes-induced ischemia of extremity and takayasu arteritis.

3. Cilostazol also be used as a complementary therapy after surgical treatment to help alleviate the symptoms, improve the circulation and inhibiting thrombosis in transplanted blood vessel.

4. It can significantly inhibit the platelet aggregation caused by various inducers and aggregates and can dissociate the aggregates without causing secondary aggregation.

5. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate.

6. It can also be used for treating ischemic diseases such as chronic arterial occlusive ulcer, pain and coldness.

Technical Test Sheet:

Items	Acceptance criteria	Results
Appearance	White to off-white crystalline powder	White crystalline powder
Solubility	It is slightly soluble in methanol, in ethanol (99.5), in acetonitrile, and practically insoluble in water.	Conforms
Loss on Drying	≤0.25%	0.07%
Residue on Ignition	≤0.1%	0.04%
Chloride	180 ppm	180 ppm
Heavy Metals	≤0.001%	≤0.001%
Assay by HPLC	98.0% ~ 102.0% (calculated on dried basis)	99.8%

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