Procaine Hcl

Synonyms: Procaine Hydrochloride; 2-methylpropyl 4-aminobenzoate hydrochloride

CAS: 51-05-8

EINECS: 200-077-2

Assay: 99.0-101.0%.

Standard: BP/USP

Packing: 25kg/cardboard drum

Character: White crystal to powder, Melting point 154-158℃, Water solubility soluble.

Usage: Active Pharmaceutical Ingredient (API), Local anesthetic for infiltration anesthesia, nerve block, etc.

Product name:	Procaine hydrochloride
Other Name	; Novocain; aminocaine; anadolor; anesthesol; anestil; atoxicocaine; 4-amino-, 2-(diethylamino)ethylester, monohydrochloride; benzoicacid, p-amino-, 2-(diethylamino)ethylester, monohydrochloride; bernocaine
Original	China
CAS	51-05-8
EINECS	200-077-2
Molecular formula	C13H21ClN2O2
Molecular Weight	272.771
Brand name	NJBNSteroid
Delivery time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	White powder
Certification	SGS, ISO 9001, KOSHER
Payment Terms	Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10g
Price	Negotiable
Usage	It is used for pain control

Description of Procaine hydrochloride

Procaine HCL is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.

For years procaine was used as a simple anesthetic, but soon researchers began to notice other curative powers of this substance. Interest in experimentation ran so high that between 1930 and 1951, over 165 reports were published on the effects of procaine in the treatment of a variety of conditions including arthritis, neuralgia, itching, peptic ulcer, asthma and hypertension. In the late 1940's three French physicians - Drs. Ghali, Boudon, and Guoit - found that procaine hydrochloride helped relieve suffering from asthma attacks. Dr. Rene Leriche discovered that procaine injections were helpful in treating certain forms of arthritis, arteritis, and blood clots in the limbs.

Clinical Application of Procaine hydrochloride

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain. Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, [citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

How it works?

Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Technical Testing Sheet

Product name	Procaine Hydrochloride
Appearance	White crystalline powder
Test Item	Specification	Result
Assay (C13H20N2O2·HCl)	99.0% to 101.0%	99.5%
Solution Appearance	Clear and colorless	Confirm
PH Value	4.0~5.5	4.35
Related impurities	impurity A: ≤0.01%	0.002%
	Single unspecified impurity: ≤0.1%	0.03%
	Total impurity: ≤0.5%	0.19%
Heavy Metal	≤5ppm	< 5ppm
Water	5.5%~7%	6.33%

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