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Product Name: Ledipasvir (GS-5885)
Synonyms: GS 5885;GS5885;GS-5885;Ledipasvir;GS-5885/Ledipasvir;
gs-5885/gs5885;Ledipasvir / GS 5885;GS 588
CAS: 1256388-51-8
MF: C49H54F2N8O6
Molecular Weight: 889.0
Product Categories: API
Categories: NS5A inhibitors;Fluorenes;Carbamates;Benzimidazoles;Cyclopropanes;
Imidazoles;Breakthrough therapy
Purity : 98%
Solubility DMSO
Storage at -20°C
Appearance : White powders
Package : 50g/foil bag
Usage : Ledipasvir is most commonly used in combination with sofosbuvir for treatment in chronic
hepatitis C genotype 1 patients. This drug has been tested and shown efficacy in treatment-naive and
treatment experienced patients.

Product Description :

Ledipasvir (formerly GS-5885) is a drug for the treatment of hepatitis C that was developed by Gilead
Sciences.After completing Phase III clinical trials, on February 10, 2014 Gilead filed for U.S. Approval of
a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. The ledipasvir/sofosbuvir
combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat
patients with genotypes 1a or 1b

Ledipasvir is an inhibitor of the hepatitis C virus NS5A protein.

Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013
showed that a triple regimen of the nucleotide analog inhibitor sofosbuvir, ledipasvir,
produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both
treatment-naive patients and prior non-responders with HCV genotype 1.The sofosbuvir/ledipasvir
coformulation is being tested with and without In February 2014 Gilead has filed for United States


On October 10, 2014 the FDA approved the combination product ledipasvir 90 mg/sofosbuvir 400 mg
called Harvoni.

Application :

GS-5885 is an inhibitor of the hepatitis C virus (HCV) NS5A protein and exhibits potent suppression of
genotype 1 HCV replicons. GS-5885 was well tolerated and resulted in median maximal reductions in
HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30
mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral
response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with
genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at
baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the
predominant sites of mutation following GS-5885 dosing. Ledipasvir (formerly GS-5885) is currently in
Phase III clinical trials.


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Competitive Advantages:

Rich experience
We specialize in this field for many years, our health care & medical products exported to Overseas, to
Europe,Africa,Asia, Americas and other country, and we have got very good feedback from our
customers,and Established long friendly relations of cooperation.

Great quality, purity and favorable.
Good quality is one of our secret success, welcome order the samples.

Safest and fastest delivery
We have Adequate stock,and can arranged within 24 hours when receive the payment.Tracking number
would be informed quickly after shipment.

We have special way could ship 10g to 100kg products a time. We offer melting powder into liquid
service.And ship the liquid in special bottles.

Good after-sales service
Tell the package update asap, and will try best solve when customer encountered various problems!

Everything is for customers
Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm
and sincere cooperation with each customer.

All in all, high quality, best service, security shipping and competitive price are our perpetual pursuance.