Acute Disorders 55203-24-2 Anti Inflammatory Steroids Dexamethasone Sodium Phosphate

Glucocorticoid Steroids Quick Details:

Product Name	Dexamethasone sodium phosphate
Other Name	DEXAMETHASONE PHOSPHATE SODIUM; DEXAMETHASONE PHOSPHATE DISODIUM SALT;
CAS NO	55203-24-2
EINECS	219-243-0
Molecular formula	C22H28FNa2O8P
Molecular weight	516.4
Melting point	262-264°C
Assay	99%

Glucocorticoid Steroids Product Description:

1. Dexamethasone sodium phosphate, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e. g., colitis); severe allergies; and asthma. Dexamethasone sodium phosphate is also used to treat certain types of cancer.

2. Dexamethasone sodium phosphate comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dexamethasone sodium phosphate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Glucocorticoid Steroids Application:

1. This medication is used to treat certain eye conditions due to inflammation or injury. Dexamethasone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids2. Dexamethasone is a synthetic corticosteroid (glucocorticoid). As such its main actions may be grouped as follows: Anti-inflammatory and Immunological Actions: Glucocorticoids prevent the development of the inflammatory response, ie. Redness, swelling, tenderness. They also inhibit capillary dilation and phagocytosis and appear to prevent the hypersensitivity responses which occur after antigen-antibody reactions.
2. Pharmacological Actions: The principal action of dexamethasone is on gluconeogenesis, glycogen deposition and protein and calcium metabolism, together with inhibition of corticotrophin secretion. Glucocorticoids also influence the mobilisation, oxidation, synthesis and storage of fats. Except for its use in the treatment of adrenal insufficiency it does not cure disease but it is used rather to treat disease symptoms because of its pharmacological properties, ie. Anti-inflammatory and anti-allergic actions.

Glucocorticoid Steroids Specification:

COA:

Product Name	Dexamethasone sodium phosphate
Appearance	White crystalline powder
Chromatographic purity	Any individual impurity not more than 1.0% Total impurities not more than 2.0%	0.27% 0.7%
Loss on drying	Not more than 0.5%	0.1%
Residue on ignition	Not more than 0.2%	0.1%
Residual solvents	Methanol≤3000ppm Methylene Chloride≤600ppm	350ppm Not detect out Not detect out Not detect out
Assay	Between 97.0% and 102.0%	99.2%
Micronixation	90% not more than 10 microns	90% not more than 10 aicrons

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