Top Purity 136-47-0 Tetracaine HCL Powder Anesthetic Anodyne for Anti-pain


Quick Detail:

Product Name: Tetracaine HCl
Alias : Tetracaine hydrochloride , 2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS NO. : 136-47-0
EINECS : 205-248-5
MF : C15H25ClN2O2
MW : 300.82
Melting point : 149°C
Assay : 99%
Grade : Pharmaceutical Grade
Storage: Closed, confined and shading preservation
Brand Name: NJBNSTEROID
Delivery time : within 24 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

Description:

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Application:

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


Specification :

COA

Product name	Tetracaine HCl
Appearance	White crystalline powder
Assay(*)	98~101.0%	100.4%
Identification	A. By UV, To match with working standard	Complies
	B: Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: it melts between 130 and 132 .	Complies
	C. A solution of 100 mg in 5 mL of water meets the requirements of the Tests for Chloride	Complies
PH Chromatographic purity Clarity	4.5~6.5	5.9
	Conform to standard	Complies
	Solution should be clear	Complies
Related Substances	Not more than the reference solution (0.05%)	Complies
Heavy metals	≤10ppm	< 10ppm
Loss on drying	< 0.5%	0.21%
Resiue on ignition	≤0.1%	0.05%
Melting range	145~150°C	146~149°C

Test Items	Specification	Test Results
Appearance	Fine, white, crystalline, odorless powder	confirm
Identification	ABC in Pass	confirm
Solubility	Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene	confirm
USP Reference standards	USP Tetracaine Hydrochloride RS. USP Endotoxin RS.	Confirm
Melting point	145~150 degree	146.0~147.5 degree
Chromatographic purity	In Pass	confirm
Related substance	Not more than the reference solution 0.05%	confirm
Heavy metals	≤10ppm	confirm
PH	4.5-6.5	5.8
Residue on ignition	≤0.10%	0.05%
Loss on Drying	≤ 0.5%	0.19%
Assay	98.0 -101.0%	100.1%
Conclusion	Confirms USP 32

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