Quick Detail:

Product Description:

1. Paclitaxel is a monomer diterpenoid compound extracted from bark of the natural plant, taxus. It is a kind of complex secondary metabolites and is currently known as the only kind drug that can promote microtubule polymerization and stabilize polymerized microtubules. Isotopic tracing has showed that paclitaxel only binds to polymerized microtubules without reacting with the non-polymerized tubulin dimer. Cells will accumulate large amount of microtubules inside cells after exposure to paclitaxel with the accumulation of these microtubules being able to interfere with various kinds of cellular functions, in particular, being able to stop cell division in the mitosis phase, blocking the normal cell division. ThroughⅡ-Ⅲ clinical study, paclitaxel is mainly applied to the treatment of ovarian and breast cancer and also has certain efficacy in the treatment of lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumors.

2. International market analysis: Paclitaxel is always the first-choice anticancer drugs in hospitals around the world. In the past few years, the cancer incidence around the world has nearly doubled compared to that at 10 years ago with lung, breast and ovarian cancer and other malignancies also showing high-incidence trend. These cancer patients are the major users of paclitaxel. From the overall perspective, before the emergence of a new plant anticancer drug being able to take its place, the sales of paclitaxel will only rise rather than fall.
3. According to the latest number released by the World Health Organization, the United States has become the country of the world's first national high incidence of cancer with the annual newly cancer cases increasing by 1.4 million, accounting for 14% of the cases of cancer patients worldwide in that year. The United States has remained the largest consumer of paclitaxel. With the increasing of US cancer incidence, the toxal is used as the major anti-advanced malignancy drug. It is believed that its sales will continue to maintain a rapid upward trend. The United States and other developed countries, during the process of 10 years of clinical use, have already summarized a set of optimal compatibility program for paclitaxel and other anti-cancer drugs. Paclitaxel has become the " backbone" for the related health sector and therefore, the demand for paclitaxel drug will still in the potential of keeping rise.

Applications:

1. Paclitaxel is a drug. It also known by its original brand name, Taxol. The drug is made from the needles of a particular type of yew tree. It works by stopping separating into two new cells, so it blocks the growth of the cancer. It is a treatment for various types of cancer, including

·Ovarian cancer

·Breast cancer

·Non small cell lung cancer.

·AIDS related Kaposi's sarcoma

Sometimes it is combined with other anti cancer drugs.

One type of paclitaxel is combined with a protein called albumin to form a drug called Abraxane. Doctors also call it nab-paclitaxel. This drug tends to cause fewer side effects than other types of paclitaxel. It treats breast cancer that has spread and pancreatic cancer that has spread.

2. It has good efficacy in the treatment of ovarian cancer and refractory ovarian cancer already being resistant to existing platinum and breast cancer. It also has good prospect on the treatment of prostate cancer, head and neck cancer, esophageal cancer, germ cell tumors, endometrial carcinoma, lymphoma, bladder cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer.