Factory Anabolic Pharmaceutical Ingredient Glucurolactone CAS 32499-92-6 for Ascorbic Acid Synthesis


Quick Detail:

Product Name	Glucuronolactone
CAS NO	32499-92-6
Einecs No	202-509-5
MF	C6H8O6
MW	176.12
Purity	> 99%
Packing	Galvanied iron barrel, net weight: 200kg±0.05
Product Categories	Pharmaceutical Intermediates; Heterocycles; Miscellaneous Reagents
Lead time	Within 24 hours upon receipt of payment
Shipment	EMS, DHL, TNT, FedEx, UPS
Uses	Use glucuronolactone as a precursor for ascorbic acid synthesis. According to The Merck Index, it is also used as adetoxicant.

Product Description:

1. Glucuronolactone, also known as D-Glucuronolactone, DGL and D-Glucoronic Acid, is an organic metabolite found in the body. A metabolite is a substance that results from the metabolism of glucose in the human liver. This water-soluble crystalline compound has been made a common component in stimulants and energy drinks like Red Bull owing to research which revealed that DGL can boost energy, lessen sleepiness and increase alertness and reaction time.

2. The human liver naturally produces glucuronolactone from glucose and controls glycogen formation. With glucuronic acid as its immediate precursor, it is used for the oral administration of the said acid in the treatment of collagen and joint diseases. It is one of the basic units of and an element of Chondroitin Sulfate and is considered by some experts to be beneficial in making joint, tendon and ligament healthy and elastic. It has also been used in medicine as an antiarthritic agent it being a vital structural component of almost all fibrous and connective tissues in animals.

3. DGL also has a direct participation in detoxifying the liver through glucuronidation. The body carries this substance which hastens and stimulates the removal of the harmful substances endogenic and exogenic noxal. Glucuronidation aids in the elimination of medicines from the body. In the process, the medicines typically consumeglucuronolactone faster than the body can naturally produce it, and so diminishing the concentrations of other substances like glycogen. Hence, DGL has been incorporated to some medicines to increase their tolerance level and improve their elimination.

Application:

1. Glucuronolactone is metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. According to The Merck Index, it is also used as adetoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase (metabolizesglucuronides), which should cause blood-glucuronide levels to rise

2. Theoretically, higher blood-glucuronides should help remove toxins from the body, leading to the claim that energy drinks are detoxifying. Free glucuronic acid (or its self-ester glucuronolactone) has less effect on detoxification than glucose, because the body synthesizes UDP-glucuronic acid from glucose. Therefore, sufficient carbohydrate intake provides enough UDP-glucuronic acid for detoxication, and foods rich in glucose are usually abundant in developed nations.

3. Glucuronolactone is a popular ingredient in energy drinks with claims that it detoxifies the body. Although levels of glucuronolactone in energy drinks can far exceed those found in the rest of the diet, the European Food Safety Authority (EFSA) has concluded that exposure to glucuronolactone from regular consumption of energy drinks is not a safety concern. The no-observed-adverse-effect level of glucuronolactone is 1000 mg/kg/day.

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